During pregnancy, the level of progesterone will likely continually fluctuate. Generally, progesterone levels can range from 1 to 28 ng/mL. As your child grows, as does this number, climbing to around 9 to 47 ng/mL at around 9 weeks into pregnancy. As you reach the 12 th week of pregnancy, the average progesterone levels will have risen to around 17 to 146 ng/mL. At the 28 th week of pregnancy until your child’s birth, progesterone levels average at around 55 to 200 ng/mL. 

If you take Clomid, your doctor will typically continue to have you monitor your progesterone levels after ovulation to make sure they rise appropriately. Progesterone supplements provide an easy fix for low progesterone levels. However, increasing progesterone levels will not prevent loss of an embryo with abnormal chromosomes after implantation. Clomid can also cause more than one follicle to develop; if you get pregnant with more than one embryo, your progesterone levels may rise higher than normal in early pregnancy.


I have been having pregnancy complications (again) and just read information regarding a possible link to progesterone deficiency. I called my provider to find out what my progesterone levels were, and learned they had never been tested! I had even been seeing a specialist for these problems, which five minutes of internet research showed me are common with progesterone deficiency! I left a message immediately requesting my levels be tested.
I was wondering if anyone has had to take a pill form of progesterone instead of cream. I just found out that my progesterone level are very low (lower than 1) and my doctor would like me to take a pill form instead of cream. Does anyone know about the side effects and/or benefits of taking pill over cream? She has chosen a bio-identical pill but I’m a bit concerned.

I am not certain how long you have tried the natural therapies you tried, but as a starting point the tips in our guide 5 Steps to Reversing Endometriosis Infertility may be helpful. Stage 4 endometriosis is often more challenging to impact with natural therapies alone, so perhaps the best form of guidance we could offer given your experience with it would be through a one on one Fertility Consultation. Click here to learn more about Fertility Consultation…

So, those can be solved, a progesterone deficiency can be solved early in a woman’s life as soon as she begins to have these symptoms, premenstrual symptoms of mood swings, fluid retention, headaches, and breast tenderness, that she gets premenstrually and these heavier periods. As soon as that happens, start taking progesterone day 15 through 28 to balance out the estrogen. That can be a godsend for a woman.
Clomid does not increase progesterone levels on its own; only if the drug stimulates production of a more mature follicle will it have any effect on progesterone levels. Some women will still need supplemental progesterone even if they take Clomid. If Clomid does not stimulate production and ovulation of a follicle, progesterone levels won't rise. Neither Clomid nor progesterone alone, or both together, will fix all the potential problems that can arise with embryo implantation.
Dr. Beverly Reed, who is an expert in reproductive endocrinology and fertility, says that levels of progesterone are at their highest in the second half of the menstrual cycle. During the luteal phase, which begins after ovulation and ends the day before your next period, progesterone is responsible for a surge of follicle-stimulating hormones to prepare for pregnancy. Just before your next period, estrogen and progesterone levels drop significantly and your period begins.2
Hi, i was diagnosed with depression and sent to a physchologist back in feb this year. I was always tired, moody, irrational, low to no libido, stressed, heavy periods,  pain in my lower abdomen, crying easily and a lot, unable to concentrate, no motivation to get stuff done. After a number of therapy sessions I was given the all clear in May. It was determined that my depression was a result of relationship issues. I’m 33years old have a 2year old son and work full time. Shortly after being diagnosed my fiancé   ended our relationship. In June I moved out with my son. I’m still getting all of the symptoms above now and my moodiness and irrational thoughts occur more during my period. I think my relationship problems were because of my symptoms above and I’m looking for reasons why I’m still having these issues when I’m no longer with my ex. I was reading the above symptoms and in my head going… Yep yep yep… Thinking I should get my hormone levels checked… What can I do to help if I do have low progesterone though?? 
It has been suggested that hormonal tests should be done via testing saliva, as opposed to blood which most doctors test. A saliva hormonal test can be done at home and then sent to a lab for analysis. After your saliva is analyzed, hormonal levels can be ascertained, helping to deduct whether you have an imbalance, be it too low or too high progesterone levels.
I had two miscarriages in a row, no live pregnancies. I was wondering ,was progesterone the culprit behind my loss. I gained nearly 10 kg by 14 weeks, without much eating. Also I had many episodes of very low blood sugar. My cycle is always regular 26 to 28 days. My uterus and ovaries are normal. But, both times growth of fetus stopped at 6 weeks.  Whatz your opinion??

I am currently in the similar if not same boat. My first son was conceived with one try 4-1/2 years ago. However it has taken 12 months for me to get pregnant this time because of low progesterone and lack of ovulation. Although my doctor suggested going on Clomid last Sept. my husband I decided to wait and keep trying on our own. I went this past Monday to confirm my pregnancy and they attempted a transvaginal ultrasound but couldn't see anything yet. They also drew blood and tested hcg and progesterone. The hcg came back 740 and progesterone (I didn't get a number) but was told it was low. SO, I am on Prometrium 200mg 2x a day. It is pill form but I have been instructed to take it vaginally, once in the morning and once at night and will stay on it for the first 12 weeks. I go back for another ultrasound in 2 weeks. My doctor said she was not suprised we didn't see anything the other day because the hcg was low - I am not far along. I know your worries - hang in there!
I had a question regarding Progesterone drops.  i am currently seeing a natural hollistic provider specifically  for infertility.  My periods are like clockwork, I am ovulating, but unfortunately had a miscarriage two months ago at 6 weeks.  The reason was unknown.  I am going to have my hormone levels checked, but wanted to ask you a question regarding the natural progesterone drops.  My friend gave me some to try for Pms symptoms.  Well, I had some cramping and brain fog on the 3rd day of my period so I decided to take 10 drops of progesterone mixed with my water.  After the fact I am now reading this can stop ovulation from happening?   Is this true?  I hope not, as I only used it the one day during my period.  We are TTC, and am worried I could have thrown things off.  I appreciate your response!!
Women who suffer from PMS are often familiar with the depressive consequence of low progesterone. Upon studying the nature of PMS, researchers discovered that not only was progesterone too low during the last 10 days before menstruation, but so was the neurotransmitter serotonin, otherwise known as the happy hormone. Serotonin is also the precursor for our sleep hormone melatonin, suggesting low progesterone is involved in insomnia.

I love this info and the podcast! My estrogen levels are normal and progesterone tested at 2 during luteal phase so my doctor put me on a low dose of bioidentical progesterone, and it’s really helped with PMS and libido and I’ve even started losing a little weight BUT I started having panic attacks and super high anxiety, which is not at all normal for me. I have Hashimotos but have normal thyroid levels and eat AIP. Any thoughts or suggestions would be super appreciated!!!
Great post and comment, very informative! Thanks everyone for sharing your insight and stories. I’ve recently started researching low progesterone bc a friend said she’s sure it the reason for the my last two miscarriages and possibly the two/ three before that. After my reading and such, I realize this has been a problem for me much longer than I could have ever guessed!! My luteal phase has always been short (11 days) so, I’ve been very thankful for the four pregnancies/ babies I’ve had. Since my last child my luteal phase has been anywhere from 4-9 days and I know that there is no way a preg can be maintained w a L phase that short. On my last mc, I started bleeding at 9 dpo and figured it was just my period again but my temp continued to rise for the next couple of days. I went in and had hcg and progesterone checked, hcg was low and progest was 8! I realize the levels fluctuate during the cycle but this was post ovulation AND after conception. Ack!!
I got pregnant with my son in 2008 on accident. Then when he was 7 months old I became pregnant with my daughter. With both I got my period back at 4 months PP even though I was EBF. We have been ttc for 10 months now. My cycles are usually 28 days, but I have had a 26 day cycle, and also a 27 day cycle within these last 10 months. I charted temp for 2 months, and the charts imply that I am ovulating. I went to a midwife because of the lack of pregnancy and also because I was having very heavy, crampy periods for the first 2 days of it. At the end of my periods (Day 6, 7, and sometimes I spot brown once or twice on day 8) I have brown thick discharge. She thought that I may have endometriosis although no tests have been run. That was just her theory I guess. I have low body temp that is usually around 96 something upon waking, but has been 95 before. I get cold very easily and have a hard time warming up. My hands and feet are also very cold. I’m extremely emotional. Around the 14th day of my cycle I was starting to get extremely nauseous to the point where I thought I was going to throw up for 24 hours straight and just would dry heave. I get very bloated and gassy randomely in my cycle. I usually have a high libido, and don’t have any problems with dryness. I THINK I have been ovulating around day 14 (if I am in fact ovulating). This month I started using Pro G Yam 500, and I also am charting this month using the billings method. I started the cream on day 9 and have been using 1/4 tsp twice daily which I think is a total of around 42mg. The billings method chart is saying that I probably ovulated on Day 12. My sex drive was high for only a few days (around when I was ovulating), and now I don’t want anything to do with my husband really. 🙂 I am now on CD20 (7DPO). I haven’t had any nausea really to speak of but I am incredibly hungry (especially for bread and sugar). I was eating a mostly paleo diet until the last few days where I just feel out of control. I usually eat organic/non dairy/grass fed meats. I also have been in kind of a hibernation mode for about a week and a half. The only place I seem to really make it to is the gym because I crave exercise. On Feb. 8th I have an appointment with an OB because I want some testing done to see what my levels are for everything. I just want somebody else’s opinion here. My reasoning for starting the cream was that I thought I was overproducing estrogen considering the symptoms I was having with the periods and the nausea etc. The end of my cycles were so much like pregnancy (because of the nausea, cravings, gassiness which I know can be PMS but I never got PMS at all before I had my two children) I kept thinking I was pregnant. I started eating a more paleo diet, even though I was already eating well, because I wanted to eliminate dairy and wheat in case it was contributing to my issues, and I wanted to take it easy on my liver. In addition to the change of diet I chose the pro g yam to help increase progesterone in order to balance estrogen and to GET PREGNANT, which is very much my main goal. Does it sound like I am on the right track? Could this natural progesterone cream be causing the intense sugar cravings and hibernation? It also could be because of the winter (freezing temps) and maybe the stress of TTC month after month. What are your thoughts? (SORRY FOR THE BOOK!)
The Natural Hormones website suggests that progesterone levels may fluctuate during the course of a woman’s normal menstrual cycle, and low progesterone levels are common during the follicular phase of the menstrual cycle. Women with low progesterone levels may suffer from estrogen dominance. Psychological symptoms of low progesterone levels in women include anxiety, irritability and mood swings. Physical symptoms of low progesterone in women include headaches and premenstrual syndrome.
I’ve got a question… I had a miscarriage in ’05. Then had a very healthy pregnancy in ’08. Since then this past Feb we tried again and I suffered a horrible miscarriage. Last month I had yet another, luckily this one was quick and my body actually took care of it all. If I have low progesterone, could this cause the miscarriages? And if so, should I be tested for this before we try to conceive again?
Fourth thing progesterone does, it does helps with the utilization of thyroid hormones at the cellular level. It helps the cells better assimilate the thyroid hormones. Remember, thyroid hormones are what enables your cells’ power plants to produce and use energy. So, you have to have good thyroid function intracellularly, within the cell. Not just what’s in your blood, but what’s in your cell in order to enable your cell’s power plants to produce good energy. If you produce good energy, optimal levels of energy, you’re going to be a high voltage individual and you’re going to be a live wire. But if you produce low levels of energy, you’re going to be a low voltage individual and you’re going to be a slug. That’s just the way it is. So, we want to make sure in everything we do, we maximize the ability of your cells power plants, the mitochondria, to produce high levels of energy.
If you are taking progesterone and get pregnant, you must continue taking progesterone until at least the 16th week. I personally would not stop if I had seriously low levels to begin with, but it is best to work with your health care practitioner if this is the case. They will continuously monitor your levels to make sure they are healthy for pregnancy.
Dr. Hotze: That’s because during pregnancy the ovaries are turned off. Why? Because the baby’s placenta is making all the hormones. Interestingly enough the hormone that promotes gestation, progesterone, is the primary hormone that is made in the womb. So, in the last trimester a woman makes very high levels of progesterone. That’s why women, oftentimes as they move towards delivery, they’ll all of a sudden get a burst of energy. They get this, they feel like they’re going to clean everything up and they have this glow of pregnancy. That’s caused by the progesterone.

Having anovulation or irregular cycles is one of the most clear signs of a hormonal imbalance. In particular to progesterone, having a short luteal phase may indicate low levels of progesterone as well as recurrent miscarriages.  Premenstrual spotting is also a sign of low progesterone levels, however, spotting can also occur during ovulation, which is perfectly normal.

Seven percent of patients will experience chest pain. Other cardiovascular risks include hypertension and heart palpitations. Progesterone also thickens the blood, making you more prone to blood clotting issues, including thrombosis and embolisms. Eight percent of patients experience a cough. Other respiratory effects include nasal congestions, bronchitis and sinusitis.


One of the first steps in protecting the health of our breasts and preventing breast cancer, is to recognize its hormonal risk factors and begin to reduce them. According to the experts, almost all risk factors associated with breast cancer are directly or indirectly linked to an excess of estrogen, or estrogen that is not sufficiently balanced with progesterone, as is the body’s accustomed way. Also known as estrogen dominance, the condition was defined by John R. Lee, M.D., as an imbalance between estrogen and progesterone in which estrogen levels can become too high relative to inadequate progesterone levels. Dr. Lee also emphasized that estrogen can become dominant whether levels are within normal range, high, or even low, if progesterone levels are even lower, relatively speaking. This is a common condition during perimenopause when hormone levels are fluctuating, and at menopause when ovarian hormone production ceases altogether. A growing number of experts believe that correcting this fundamental imbalance is at the heart of preventing and treating breast cancer.
The female hormones estrogen and progesterone work together to prepare a woman's body to conceive a child each month. As an egg ripens in one of the ovaries, the lining of the uterus begins to proliferate under the influence of rising hormone levels, according to Dr. Lauralee Sherwood in her book, "Human Anatomy." Once an egg is ovulated, if fertilized, it will implant in the uterine lining. Progesterone from the corpus luteum, a part of the ovary, then maintains the uterine lining until the placenta forms.

Dr. Hotze: They can’t patent it. Can’t make any money on it. The other thing that can cause migraines, by the way, is food allergies. Common foods: wheat, corn, egg, milk, yeast, and soybean are the big six, but any food can cause food allergies. One of the food allergies, very commonly, is migraine headaches. So, if progesterone doesn’t solve the problem or magnesium, it may be a food allergy on that.

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Oct 1st, 2018), Cerner Multum™ (updated Oct 2nd, 2018), Wolters Kluwer™ (updated Oct 2nd, 2018) and others. To view content sources and attributions, please refer to our editorial policy.
Progesterone naturally metabolizes in brain tissues to the metabolite allopregnanolone, which is known to produce calming, anti-anxiety and possibly enhanced memory effects.  There is some speculation that it could be important in preserving cognitive function in women experiencing the decline in progesterone levels with age.  However, it’s important to note that progesterone is produced by brain tissue itself, and so the reduction in blood progesterone levels as ovarian production decreases may not be as important as other aging processes that have direct effects on the brain’s function.  It will be interesting to see further research on this as aging women increasingly use progesterone in hormone replacement.

A: Progesterone is available in several different forms including pills to be taken by mouth, tablets to be inserted into the vagina, and as an injectable medicine. Progesterone also has many uses for female health and regulation of ovulation and menstruation. The most common side effects of progesterone are bloating, breast tenderness, diarrhea, dizziness, drowsiness, dry mouth, headache, heartburn, acne, increased hair growth, vaginal itching or dryness, irritability, muscle pain, nausea, stomach pain or cramping, and vomiting. In addition, some progesterone products contain peanut oil; these products should not be taken by people who are allergic to peanuts. Progesterone may affect blood sugar levels and should be used cautiously in patients with diabetes. Progesterone may increase the risk of developing blood clots. Patients need to notify their healthcare practitioner if they will be having surgery or be confined to a bed or chair for a long period of time (such as a long plane flight). Progesterone should only be used during pregnancy if directed by a physician. If a patient is pregnant or breastfeeding, they should consult with their doctor or healthcare practitioner to discuss any potential risks to the baby. For more information, please consult with your healthcare provider and visit //www.everydayhealth.com/drugs/progesterone. Michelle McDermott, PharmD
Trouble conceiving is frustrating and can absolutely be due to low progesterone. There are herbs, vitamins, and bioidentical hormones on the market that are often prescribed by naturopathic doctors to boost progesterone levels. The medicine and dosage specific to you depends on many factors, mainly your current blood, urine or saliva progesterone levels. I suggest getting a work-up done with a naturopathic physician and having your whole hormonal picture assessed, including current progesterone values. Further, hypoglycemia is not directly correlated with infertility but it’s best to have blood sugars balanced and this could certainly be a stress on your system that impedes ovulation or implantation. Please keep me posted. Warmly, Dr Julie
Progesterone is one of the major female hormones, along with estrogen, produced by the ovaries. These two hormones work together to regulate a woman’s menstrual cycle. Natural progesterone has an identical chemical structure to that made in a woman’s body by the ovarian corpus luteum. It is not the same as the synthetically derived progesterone referred to as progestins, which are chemically modified and recommended by conventional doctors. Progestins have the opposite effect to natural progesterone. They are used as morning after pills to trigger abortions and in birth control pills. To be clear, this discussion deals only with natural progesterone.
Nikki actually did a little self-discovery on her family’s diet as well. She said her family had always eaten a healthy diet… BUT, that they were a family that did eat pasta, sandwiches and whole grains. So she has cut out gluten and tried to eliminate as much processed sugar and carbs as possible so that she can prepare for a future attempt at pregnancy.

I am 24. For the past two years I have been a medical guinea pig. My problems started out by having horrible painful cramps and sometimes breakthrough bleeding in my second week of ovulation and also during my actual period. After being on 8 different forms of BC, depo provera (which I got pregnant with my son on) I had other forms of BC includong Apri, two forms of Zovia and Zovia combined with a 5mg Provera pill. Everytime they switched my BC I would get better for a cycle and then come back even worse. My horrible cramps and breakthrough bleeding were then added onto with hot flashes, night sweats, weight gain, inability to self lubricate,and more pain. After three ultrasounds and a laparoscopy I decided to ask..”hey why havnt we done any bloodwork”? I had bloodwork done just before I got off zovia and six weeks later to compare. Being off birth control did wonders for me! All my added symptoms disappeared but I am still back to horrible period cramps and breakthrough cramps. I was told friday that my labs indicated my estrogen to progesterone ratio is 10.8 to 5.2 and they want to begin me on a 12 day/mo natural progesterone supplement. I am to start it next week. I eat very very healthy (portion, fresh produce, unlrocessed meats, etc) and do light jogging and yoga often. I am naturally high strung and suffer from OCD. I cant lose weight and Infact am overweight. Being a 3rd shift mom with a 3 & 6 year old doesnt help my disorder either. What is your opinion on my case?

Hormone testing can be performed by a medical doctor, naturopathic doctor or by an at-home testing service. Testing options range from charting your menstrual cycle to determine the length of your luteal phase, to basal body temperature tracking during your luteal (consistently low BBT may indicate low progesterone production), to taking saliva or blood tests to find out your progesterone levels. The questionnaire above helps to point out signs of progesterone deficiency while these tests help to confirm it.


The genitourinary system includes the breasts and vagina. The gastrointestinal system includes the stomach and intestines. Twenty-seven percent of patients experience breast tenderness, 11 percent experience urinary problems and 10 percent experience vaginal discharge. Patients may also experience vaginal dryness, breast pain and breast enlargement. Progesterone use may also trigger breast cancer. Twenty percent of women will experience abdominal pain and 8 percent will experience bloating, diarrhea and nausea.
Some women require progesterone supplements. Birth control pills may contain progesterone analogues, menopausal women occasionally use progesterone to alleviate uncomfortable symptoms and prevent disease, and pregnant women who have low progesterone may be prescribed progesterone supplements to prevent miscarriage. Drugs.com notes that the side effects of high progesterone associated with supplementation are similar to those of high progesterone that's produced naturally by the body. In particular, supplement-related side effects may be even more exacerbated than those related to normal hormone production, because progesterone levels may become quite high. Women frequently note vomiting, dizziness and cramping in addition to the typical symptoms of progesterone associated with menstruation or pregnancy.

The ‘pill’ is often prescribed as the solution to reproductive disorders, yet it’s designed to attach the drug progestin (not progesterone) to the progesterone receptors to block the uptake of progesterone thus preventing ovulation. The problem is if we don’t ovulate we don’t produce progesterone. Balanced progesterone levels are essential for a healthy reproductive system.
I am 37 and have always had incredibly thick hair, recently it has started thinning all over my body. Not Falling out in clumps but actually  thinning in diameter and strength. I’m also getting really dry skin, combined with a little bit of acne and wrinkles around my eyes. This has all been very sudden occurring within the span of maybe two or three months. Does this sound like a hormonal and balance? 
Estrogen dominance is more common than not. Estrogen stores in the tissues (liver, skin, etc.), and a blood test cannot detect the overall estrogen value. It is likely that if the serum level of estrogen is low, it’s raging high in the tissues, making “low estrogen” a misnomer. It’s almost better to have a higher serum estrogen level because you know your body is producing it out of necessity. Estrogen, by physiologically definition, can never get low. Ray Peat gets into the nitty gritty in this interview: http://www.blogtalkradio.com/eastwesthealing/2011/03/15/ray-peat-estrogen-vs-progesterone
Hormone replacement therapy (HRT). After menopause, many women turn to progesterone replacement therapy to sustain premenopausal levels. However, while receiving HRT, levels could become fundamentally disproportionate. This could increase a woman's chances of contracting progesterone dominance symptoms, such as bloating and fluid retention among others.

Usually a cup of red clover tea helps when the hot flush comes on but they take time to go down and are very unsightly because they are patchy and look like I’ve been sunburnt or scalded with hot water. I don’t feel hot through my body, just on the skin itself which is hot to the touch and then only on my elbows, which sometimes migrates to the backs of my hands, and patchy uneven red on my face. It’s quite unusual, from what I can gather.
I don't know of any diet that would increase your progesterone. Mine was so low that I had to take injections twice a week for nearly the entire pregnancy. Most doctors will only test for progesterone in the first trimester and not after that. Had I followed normal procedure, my daughter would not have made it. I could feel my progesterone begin to drop and I would begin to go into labor.
Non-pregnant women who are not on birth control pills or hormone supplementation naturally experience their highest progesterone levels approximately one week after ovulation, with levels falling and side effects diminishing in the subsequent week. For women who are pregnant, however, progesterone levels increase dramatically in the early weeks of pregnancy, leading to many of the classic first trimester symptoms, according to Heidi Murkoff and Sharon Mazel in their book, "What To Expect When You're Expecting." Exceedingly sore breasts, frequent headaches, moodiness and nausea are all commonly associated with early pregnancy. While these symptoms of high progesterone are similar to the symptoms experienced by non-pregnant women during their natural high-progesterone phase of the menstrual cycle, they're exacerbated by the extremely high levels of the hormone associated with pregnancy.
The ‘pill’ is often prescribed as the solution to reproductive disorders, yet it’s designed to attach the drug progestin (not progesterone) to the progesterone receptors to block the uptake of progesterone thus preventing ovulation. The problem is if we don’t ovulate we don’t produce progesterone. Balanced progesterone levels are essential for a healthy reproductive system.
If you track your cycles and find that you ovulate on day 19 for instance, then taking your progesterone levels on day 21 will show that you have low progesterone, but your progesterone might not even be low. 7 days after ovulation in this case brings us to day 26. A blood draw on day 26 would give you an accurate measure of your progesterone levels in this example. After confirming that you ovulated on day 19, you’d have to be tested on day 26 in order to get an accurate reading of your progesterone levels.
When we got “the talk” about periods, sex, and baby making, most of us learned what happens without much understanding of how it happens. Yet more women than ever are looking for answers about irregular or painful periods, trouble conceiving, or carrying a baby to term. In all of these issues, one common denominator keeps coming to the fore: progesterone. 
@Anna, Well, now I don’t feel so badly for being starving this week! (I’m in my luteal phase). This makes perfect sense – I’ve been craving fatty things like avacados, not sweets, which I attributed to my body trying to prepare itself for possible pregnancy. So low estrogen also leads to low progesterone? I have low estrogen, and have many of the symptoms above. I didn’t know the two went together. I’ve been afraid to try to do anything about low progesterone symptoms because everything for that seems to lower estrogen levels, which I don’t want. sigh. Like I posted below, I am confused about all of this.

Non-pregnant women who are not on birth control pills or hormone supplementation naturally experience their highest progesterone levels approximately one week after ovulation, with levels falling and side effects diminishing in the subsequent week. For women who are pregnant, however, progesterone levels increase dramatically in the early weeks of pregnancy, leading to many of the classic first trimester symptoms, according to Heidi Murkoff and Sharon Mazel in their book, "What To Expect When You're Expecting." Exceedingly sore breasts, frequent headaches, moodiness and nausea are all commonly associated with early pregnancy. While these symptoms of high progesterone are similar to the symptoms experienced by non-pregnant women during their natural high-progesterone phase of the menstrual cycle, they're exacerbated by the extremely high levels of the hormone associated with pregnancy.
If you have endometriosis, Dr. John Lee recommends using progesterone from days 8 to 26 of your cycle, to reduce the effects of estrogen on the body (estrogen stimulates endometrial growth). Take a short week off to refresh your receptor sites. He has had success with controlling symptoms within six months. Once the outbreaks of endometriosis are tolerable reduce the usage to day 14 until your menstrual cycle begins.
Pro-gestation hormone, often shortened to progesterone, is an anti-inflammatory hormone produced before ovulation to enhance the possibility of becoming pregnant. It has a calming, soothing effect, raises serotonin levels in women's brain, which helps cope with depression and insomnia. And, of course, progesterone is vital for maintaining a healthy pregnancy. Unfortunately, though, a lot of women of postmenopausal age and kids suffer from a progesterone deficiency which may lead to many health problems, including infertility.

I have suffered from horrible, debilitating fatigue for over 3 1/2 years. Just recently I was thinking that possibly I have a hormone imbalance. I have a lot of brain fog, am very much irritable/don’t have much patience, very dry skin/nails are only slightly brittle, and a non-existant libido. I was never able to nurse/had chronically low supply and the only reason I am mentioning this is because it is so very rare for this to happen. And my hair dresser can’t even properly do my hair anymore because it acts so strangely- she said there has to be something hormonally wrong going on (and she has done my hair from a very young age). I do technically have hypothyroidism although I have been treated with synthetic and NDTs. The worst my TSH was though was only 4.76 (when I was unmedicated) so I doubt that it could cause it. Anyways, thanks for posting. I hope that some how I will be able to get to the bottom of all of this. I can handle almost anything besides the horrible fatigue/exhaustion.


BUT; can you please explain to me, why do I experience acne breakouts a good week before period? This surely must be connected to hormonal changes due to menstrual cycle (as it is so obvious). As I understand, the hormones that changes drastically a good week before is progesterone. Can progesterone cause acne when high? Then why everyone says testosterone is the culprit(in general) for acne?
I am 34. My DH and I have been trying to conceive for 7 years. I have done tons of researching!! We have been medically checked and told we have unexplained fertility. My hormone, and thyroid tests came back good. I have spent 2 years BBT. Temps ranging 96- 97.4 pre O and anywhere from 97.6- 98.2 post O. My temps fluctuate a lot. I became very frustrated with temping and finally gave it up. I have a short follicular phase. Will see O fluids as early as 7 days past period. My cycles range from 24 to 27 days with 2-4 days of brown spotting before period actually starts. I have tried so many different herbs. Did the whole vitex thing only to quit when I discovered the negative side of it. I’ve done progesterone cream, but always stopped before too long as I did not want my body to become dependent on it. I have symptoms of low progesterone and find in frustrating to know how to correct it. We eat a VERY clean organic paleo diet. Have been for 2 years.
First, a patient’s medical history is assessed. The lack of regular menstrual cycles suggests a problem, such as with Polycystic Ovarian Syndrome. Previous pregnancy losses may be a sign of inadequate progesterone production. Properly timed blood tests to measure progesterone levels may be done in the woman who has regular menses. A biopsy of the uterine lining may even be done (although an uncommon practice these days) to determine a lack of progesterone effect. Sometimes, progesterone is used empirically, that is, just to make sure the level is normal, since you can’t have too much progesterone!
In the 1990's an American medical doctor, John R. Lee, pioneered the use of natural progesterone in treating breast cancer, PMS and menstrual problems. Dr Lee emphasised the use of natural progesterone with its dynamic and holistic properties, and warned doctors to avoid synthetic progesterone look-alikes or analogs, because they were not as effective and have nasty side-effects. Unfortunately many doctors are not aware of this important distinction. Pharmaceutical companies promote only their more profitable patented look-alikes. The best-known look-alikes are various progestins and progestogens.

I was actually diagnosed as infertile due to a lack of ovulation…. which I decided on my own was wrong. I’m an herbalist, so I’ve spent the past 7 years intensively studying the herbs used for hormonal balance both because I so desperately wanted to have children… and I think ultimately I was meant to share my journey. At any rate, what I found out on my own once away from the doctors was that I had a progesterone deficiency… I suspect this is a hormonal imbalance that can start in the womb, so it might be interesting to take a look at your mom and grandma if you still can. A big tip off for me, besides the short luteal phase was the brown discharge that occurred in my monthly flow. Ironically, I always thought that was normal because my mother had always had it as well. It’s a big sign that your progesterone is not sufficient to fully flush your uterine lining the month before and your womb is just constantly trying to get rid of left over blood each succeeding month. My mom also had a number of miscarriages and I was the only pregnancy to go full term. What’s great about this little symptom is that as I achieved balance, I could very clearly see a different cycle- one that was red from end to end. After a couple years working with the herbs (and a whole foods diet of course) I had my first child… and then I got pregnant by surprise about 18months afterwards! I believe I can see some symptoms of my chronic low levels returning- though my cycle remains red… so I’m going to have to start back into my routine.
One mysterious effect in the progesterone intolerant women is bladder problems.  Some women have either a great increase in urinary tract infections or a feeling like they are having an infection as soon as they try taking a "normal" progesterone dose.  If bladder symptoms start and stop with starting and stopping progesterone, they may be related.
Hi- I’m 32 and my husband and I have been trying for our first baby- 11 months without luck. I was on birth control for 15 years and since being off, I start spotting a week after ovulation until I get my period which I’m sure is contributing to our issue. My 3rd day hormone check came back normal but I can’t imagine this is normal. I’m assuming I have a progesterone deficiency… thoughts?
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