Although a number of studies over the years have pointed to elevated breast cancer risks among users of synthetic hormone replacement, the Women’s Health Initiative (WHI) was the first major clinical trial of its kind to study their impact on bodily health. Results revealed greater risk than benefit among HRT users in terms of heart disease, stroke, and blood clots and a 26% increase in breast cancer risk; the trial was abruptly halted. Naysayers were quick to point out that since only one type of hormone replacement was used in the study—PremPro, a synthetic estrogen and progestin combination that was the number one prescribed HRT for women—the results could not be applied to all forms of HRT use. And that further, the average age of women subjects in the WHI was over 60 so the results could not be representative of most women on HRT. These conclusions were swiftly challenged by the Million Women Study published in the prestigious medical journal, The Lancet, [HRT use and Breast Cancer, Cancer 2003;97:1387–92.] which found that, “use of HRT, by women in the UK over the past decade has resulted in an estimated 20,000 extra breast cancers.” Note to WHI naysayers: The women in this study were between 50 and 64 years of age and a full 15,000 of these cancers were associated with any combination of estrogen-progestin.

Sorry if that bothers you. 🙂 I do know the difference, I am just my own worst editor! I read it how I meant it to be written, so sometimes I don’t always catch all of my typed errors and the spell/grammar check doesn’t either. I know some people are hugely bothered by grammatical errors (I only have a few pertaining to grammar that really get to me!) so I to try and catch what I can!

I’m sorry about the challenges you’ve been facing. I am unable to offer any treatment suggestions online but it does sound like your hormones need a tune-up. My suggestion is that you get in to see a naturopathic physician and ask for a comprehensive hormone panel. I recommend a urine panel, to get a closer look at what might needs balancing. Progesterone imbalances are likely accompanying some other hormonal imbalances and it’s worth finding out where you specifically need support. Warmly, Dr Julie
Dr. Hotze: They can’t patent it. Can’t make any money on it. The other thing that can cause migraines, by the way, is food allergies. Common foods: wheat, corn, egg, milk, yeast, and soybean are the big six, but any food can cause food allergies. One of the food allergies, very commonly, is migraine headaches. So, if progesterone doesn’t solve the problem or magnesium, it may be a food allergy on that.
If you take Clomid, your doctor will typically continue to have you monitor your progesterone levels after ovulation to make sure they rise appropriately. Progesterone supplements provide an easy fix for low progesterone levels. However, increasing progesterone levels will not prevent loss of an embryo with abnormal chromosomes after implantation. Clomid can also cause more than one follicle to develop; if you get pregnant with more than one embryo, your progesterone levels may rise higher than normal in early pregnancy.
Luteinizing Hormone (LH) stimulates the ovaries to release an egg and start producing progesterone – a hormone that prepares the uterine environment to nurture a fertilized egg. LH can be found in a woman’s urine just before ovulation occurs. Over-the-counter tests that help predict ovulation measure this increase of LH via a urine sample. Urinary LH testing is commonly used to help time intercourse in order to improve pregnancy chances.
If the woman does not become pregnant, the corpus luteum breaks down, lowering the progesterone levels in the body. This change sparks menstruation. If the body does conceive, progesterone continues to stimulate the body to provide the blood vessels in the endometrium that will feed the growing fetus. The hormone also prepares the limit of the uterus further so it can accept the fertilized egg.
Low progesterone is associated with, but does not cause, infertility. There is no effect on fertilization of your eggs or the implantation of an early embryo in your uterus. However, low progesterone can interfere with further development of your embryo and fetus after implantation. This can lead to a nonviable pregnancy or miscarriage during your first trimester.
If you find that it takes a bit more energy to keep your cool or that you are no longer sleeping through the night I encourage you to look to progesterone as a way to help.   You can go to and take a free hormone quiz to see where you might lie and what you can do with nutrition, supplements and lifestyle changes to feel even better.

Men should use 10-100mg per day. This is suitable to treat symptoms of low progesterone, symptoms of low testosterone, or more commonly, symptoms of estrogen dominance caused by xenoestrogens. Vary the dose depending on the severity of the symptoms. The amount of progesterone to use is not dependent on your weight, size, height or age, but on your symptoms.
High progesterone levels don't preclude normal reproductive function, but they can exacerbate some of the side effects of the menstrual cycle. Many women experience headaches, moodiness, breast tenderness and fatigue as they approach their period. It is during this time that progesterone levels are highest. Women who have particularly high progesterone levels tend to have more severe pre-menstrual symptoms than those with naturally lower levels, Sherwood says. For most women, progesterone-related side effects diminish as hormone levels drop later in the cycle.

If you have symptoms of abnormal progesterone levels in early pregnancy, doctors may take a blood test. They will check that progesterone levels are not too low or too high. The Journal of the Turkish-German Gynecological Association reported that progesterone levels can be an indicator of the health of the pregnancy. Low progesterone results could indicate a risk of miscarriage.7

I’m not Jordan, but my holistic DO ordered me a 24 hour saliva test to test for adrenal fatigue as well as hormones. So four times in one day I had to put a saliva sample in a tube to check and see what my cortisol levels were doing. You can order this test yourself from some independent labs (HealthCheck USA comes to mind). I haven’t heard of many regular docs ordering it though. My MD laughed and said it was a waste of money…….and yet it was the test that finally showed how bad my adrenal fatigue was!
Are you aware of any link between insufficient glandular tissue/breast hypoplasia and low progesterone? I’m wondering if my primary lactation failure after the birth of my daughter 2.5 years ago may be linked to a more recent miscarriage and my current struggle to conceive. Additionally, early in my first pregnancy my hcg levels were very slow to rise, in hindsight I believe my doctor was monitoring me for a loss, which, thankfully, didn’t happen. As I’m not struggling to get pregnant again I’ve been doing lots of reading and am wondering if all that’s things may be connected, and if low progesterone may be part of the problem. I also suffer from most of the symptoms you mentioned. I also think my luteal phase is too short, maybe between 8-10 days. 
Dr. Kimberly Langdon Cull is a University-trained Obstetrician/Gynecologist with 19-years of clinical experience. She delivered over 2000 babies and specializes in gynecologic diseases such as menstrual disorders, infertility diagnosis and treatment especially pertaining to tubal blockage and polycystic ovarian syndrome (PCOS). Dr. Langdon is the inventor of 6 patent pending medical devices, and attended Ohio State University from 1987-1995 receiving her Medical Doctorate Degree (M.D.) with Honors in Obstetrics and Gynecology.
There are a variety of hormonal abnormalities that can lead to infertility. Examples are hypothyroidism (low thyroid function), hyperprolactinemia (high male hormone levels) and luteal phase defect (low progesterone levels). Our physicians are experts in treating these and other endocrinological abnormalities. The IHR experts work closely with couples undergoing the many different types of assisted fertility treatments available. We are renowned for our specialized knowledge and high infertility success rates even in difficult cases. IHR's expertise in hormonal infertility lies in our willingness and ability to individualize our approach to best suit each and every one of our patients. If you have any questions as you review the material on hormonal infertility, please contact us for a FREE Hormonal Infertility E-Mail Consultation.
I tried bio-identical hormone pills and the side effects were not worth it AT ALL, they were HORRIBLE. First of all I thought I was pregnant and from what I read this is a common side effect and some women put up with this monthly hoping their body will produce enough progesterone to keep a pregnancy viable… I used them for 2 months – as Rx by my naturopath, a couple days after ovulation until I started my period (or got pregnant whichever happened first). The first month was not bad, didn’t notice huge change in my body, felt like normal pms. I am in my 40’s and she felt this would be a good idea for me. The 2nd month I was super excited because I was having all the pg symptoms, including crying over nothing. I didn’t use the progesterone after that, ** What I did notice when I cut out sugar 100% (I ONLY used pure maple sugar sparingly, no artificial sweeteners, honey, sugar, cane sugar, etc) last fall was that my body was producing a TON of CM for those 2 months (sorry for TMI but for those of us hoping to get pregnant this is good news). I had cut out sugar because of health issues, originally was told could be interstitial cystitis but ended up to be IBS (remedied mostly by a Low FODMAP diet). My bladder was on fire and so urologist thought it was my bladder. I also cut out gluten and most grains, and only ate vegetables and once in a while fruits and full fat meats but grass fed and organic. I did have withdrawal headaches for 2 weeks but would do anything to relieve the symptoms (turns out I had a flare up and so the pain was intense for 6-8 weeks, flu-like symptoms, achy, etc). Once I changed my diet my symptoms were much less, funny how the foods you should eat if you have interstitital cystitis are what you should avoid with IBS. With much prayer and research I changed my diet. I started eating sugar again (uugh!) because we made christmas cookies and well one thing led to another and I am back on the sugar train. I REALLY want to cut out all sugar again, this includes honey b/c it’s high in fructose and I am supposed to avoid fructose on a Low FODMAP diet. The good thing is when I cut out sugar I didn’t crave it at all and I had TONS of energy! And when I tried to eat a small piece of cake, I thought I was going to be physically sick from the sugar. Sugar is as addicting as heroine from what I heard, anyways, I am going to try and know I can do it, one day at a time.
Thanks for your comments Dr.Lam. Ufortunately there is not possible to have doctors consultations about hormon issues in holistc way. I am living in Sweden and tried to talk to my doctor about hormons… I get energy crash in beggining of menopause and tried to menage it with progesteron (some intervals) and stress management, like life style changes, vitamins, minerals, nutritions, exercizes , etc. but I feel after 2 years (now I am 53) that energy still very low, and I feel dizzyness, brain fog, decrease memory and I get joints pain in arms mostly (menopausal arthritis?). My blod test is ok according my doctor(including RE factor, cortisol, B12,D, Hb etc.)
Hi Karoline, thank you for sharing your story. Your hormone panel being menopausal won’t be a surprise, low estrogen, low progesterone and testosterone, so you may want to get your thyroid panel done just to check on things. One of things that happens when we get low estrogen is weight gain. No matter what women do the weight just stays in an effort to keep estrogen stored. There are bio identical hormones available that don’t have the same health issues the synthetic one cause and are good support for this time. I don’t think it would hurt to have a thyroid panel done to ease your mind but we just have to support our bodies with herbs and progesterone cream in an effort to balance to things out. Be sure to have testosterone tested too.

Men should use 10-100mg per day. This is suitable to treat symptoms of low progesterone, symptoms of low testosterone, or more commonly, symptoms of estrogen dominance caused by xenoestrogens. Vary the dose depending on the severity of the symptoms. The amount of progesterone to use is not dependent on your weight, size, height or age, but on your symptoms.

Interesting. I had a baby 4 months ago and I know my hormones are not rebalanced yet and I’ve been trying to puzzle out what exactly is going on and what to do. This provides more information for me. I’d love to see more nitty-gritty on hormones in the body and balancing the endocrine system (interactions between hormones, herbal and dietary interventions, etc). Obviously where I am is a little different because I’m breastfeeding and that changes my hormones but I’m very curious what is normal post-pregnancy and how long it should take to return to normal, and what ‘normal’ even is, hormonally. Thanks!
I have low progesterone as well as my 3 sisters. However I did not need progesterone to fall pregnant with my now 18 month old boy. My sisters and I all went through the saga of convincing our doctors this was the issue. I was on the max dose of progesterone suppositories through my entire pregnancy and although at one point it looked like my body was building its own supply I continued on with the suppositories. All I can say is trust your instincts. Too much Progesterone is not really an issue, so go with what you feel is right and don't let your doctor persuade you otherwise.
Hi Amy, post partum time is always tricky as having a new born and then toddler does wear on the adrenals. I would use the foods in the article to try and boost your progesterone naturally. Progesterone is the hormone responsible for holding the pregnancy so if you are not conceiving it could be for other reasons. Give your body time to recover and try not to get too stressed out about it because stress contributes to fertility issues. Please let us know if you have more questions.