Hi, i was diagnosed with depression and sent to a physchologist back in feb this year. I was always tired, moody, irrational, low to no libido, stressed, heavy periods,  pain in my lower abdomen, crying easily and a lot, unable to concentrate, no motivation to get stuff done. After a number of therapy sessions I was given the all clear in May. It was determined that my depression was a result of relationship issues. I’m 33years old have a 2year old son and work full time. Shortly after being diagnosed my fiancé   ended our relationship. In June I moved out with my son. I’m still getting all of the symptoms above now and my moodiness and irrational thoughts occur more during my period. I think my relationship problems were because of my symptoms above and I’m looking for reasons why I’m still having these issues when I’m no longer with my ex. I was reading the above symptoms and in my head going… Yep yep yep… Thinking I should get my hormone levels checked… What can I do to help if I do have low progesterone though?? 
Hi, i am 49 and definitely in Peri menopause for sure. I do have fibroids, but they have never really given me much trouble except for heavy periods. Last year i did have a lot of stress, including my wedding which ironically was the month i started having prolonged periods. They would go on for about 2 weeks, then a 35 day cycle until my next. Some months were great, some i had two periods in a month, or spotting that would then lead to a period. I have kept a journal so i can show my GP, and have (since last November) removed alcohol from my life, except for an occasional drink, lost weight through healthy eating and exercise, and as such have had no period problems since. This year my cycles have been 28 days, to some months being as long as 35 days, 7 day duration, and not overly heavy. March was the only odd month where i had a two day period, then they turned up again two weeks later.
The progesterone prescription products that have been approved by the Food and Drug Administration (FDA) are LIKELY SAFE for most people when used by mouth, applied to the skin, applied into vagina, or injected into the muscle with the advice and care of a healthcare professional. However, progesterone can cause many side effects including stomach upset, changes in appetite, weight gain, fluid retention and swelling (edema), fatigue, acne, drowsiness or insomnia, allergic skin rashes, hives, fever, headache, depression, breast discomfort or enlargement, premenstrual syndrome (PMS)-like symptoms, altered menstrual cycles, irregular bleeding, and other side effects.
Saliva can also be tested for progesterone levels. Although saliva contains much less blood stream progesterone levels, the hormone can still be measured. This test can be performed by a doctor or with a home test kit, but all results should be discussed with a doctor. The validity of this test is still in debate in the medical community, and buyers of home test kits should beware that the success rates of home tests are not always valid.

In my opinion having 2 M/C's does not mean that you are having issues. M/C are generally the bodies way of dealing with an issue. I had several misscarriages and they were not caused by fertility issues. As it turned out my husband and I were incompatible and after several tries we finally had our son. Talk to your Dr before making assumptions that the m/c's were nothing more than your body making the correct choice for it.


I’m curious what you ladies would consider low progesterone? Do you go by symptoms or BBT levels, or numbers from the doctors? I know that a progesterone draw at 7 dpo should be at least 5 to show ovulation occured, and at least 10 to sustain pregnancy (some say 15). But what are your own thoughts? How would one decide they do have low progesterone? And what are they shooting for as “good” progesterone?
Estrogen and progesterone play a seesaw game over the course of a month, and over the course of your life as a woman.  Estrogen is needed to stimulate your ovaries and grow your uterine lining in the first part of your cycle.  This strong first half leads to strong progesterone in the second half, unless something goes wrong. The following points can all be causes of low progesterone.
The widespread and common use of natural progesterone (hereafter referred to as progesterone) for hormone balance and menopausal symptoms, especially estrogen dominance, has potentially important negative clinical implications when used by those with a weak body ? such as those with Adrenal Fatigue Syndrome (AFS). Excessive progesterone can cause imbalances with many other hormones in the body, making progesterone side effects and toxicity both serious and hard to identify. Extreme caution should be used when considering progesterone, and this article details why.
I was in your shoes a year ago. My daughter was conceived while I was on the pill so we never expected to have problems when trying for baby #2. I had three early miscarriages, all between 5 and 6 weeks and the doctor could never figure out why. I had SO many blood tests that I was surprised I had any blood left ;-) My husband and I even did genetic testing and again, everything looked perfect. For no reason we can understand, I am now 32 weeks along! What is weird is that when this one was conceived, we had just found out that we were moving to a new state and my husband would be away from us for five weeks before my daughter and I would be able to move to be with him. I am still shocked that an unborn baby could thrive during that stressful time, especially when the other times I was pregnant, life was easy!
Hello, I have PCOS and started to take progesterone cream on day 12 of my cycle. Today is day 21 and I started bleeding and cramping a little. I’m not sure if it is a period or just spotting, but should I continue taking the progesterone cream until day 26 ? Can you tell me what should I do if it is just spotting, and what should I do if it is a period ? Thanks a lot.
Are you aware of any link between insufficient glandular tissue/breast hypoplasia and low progesterone? I’m wondering if my primary lactation failure after the birth of my daughter 2.5 years ago may be linked to a more recent miscarriage and my current struggle to conceive. Additionally, early in my first pregnancy my hcg levels were very slow to rise, in hindsight I believe my doctor was monitoring me for a loss, which, thankfully, didn’t happen. As I’m not struggling to get pregnant again I’ve been doing lots of reading and am wondering if all that’s things may be connected, and if low progesterone may be part of the problem. I also suffer from most of the symptoms you mentioned. I also think my luteal phase is too short, maybe between 8-10 days. 
IHR has treatments for a variety of conditions, including hormonal infertility, ovulatory dysfunctions, endometriosis, immunological infertility and many others. Perhaps less known is our work with individuals and couples who are considering assisted reproduction, but who are uncertain of their next step. We encourage anyone, before they make a decision, to consult with us. Currently, we are offering a FREE Hormonal Infertility E-Mail Consultation.
I have so many of the symptoms you have listed. I have suffered three miscarriages before having my sons. I needed progesterone(shots) when I was pregnant with both of my sons(13 & 14) . Now @ the age of 44 I had a emergency hysterectomy 6wks ago after hemorrhaging on day 14 of my period. I never thought to have my progesterone tested after having my children. I will defiantly do this @ my 8wk post-op. Do you feel otc progesterone cream(organic) can be beneficial? Thanks!

Hi! I had a miscarriage almost 3 years ago and have been struggling since. In the year after I had to be given medication to start my period twice that I can remember. Also I started having insane night sweats two weeks before my period. In the last six months I have started to gain weight rapidly despite diet changes and exercise. My reg dr had put me on antidepressants for all of these symptoms but I knew something still wasn’t right. I’m 27 and healthy so I don’t think my GP even thought to check my hormone levels. I recently saw a dr that practices more holistic medicine she checked and low and behold I have low progesterone!  I’m consulting with a bio pharmacy on Monday. Will this help with the weight gain? 


I have low progesterone as well as my 3 sisters. However I did not need progesterone to fall pregnant with my now 18 month old boy. My sisters and I all went through the saga of convincing our doctors this was the issue. I was on the max dose of progesterone suppositories through my entire pregnancy and although at one point it looked like my body was building its own supply I continued on with the suppositories. All I can say is trust your instincts. Too much Progesterone is not really an issue, so go with what you feel is right and don't let your doctor persuade you otherwise.

Dr. Hjort cites progesterone in pregnancy as an area of “intense debate” among OB-GYNs and reproductive endocrinologists (sub-specialists who manage infertility, recurrent pregnancy loss, and hormonal imbalances in women). “Half of them believe that a progesterone deficiency is a real thing and the other half of them believe that it’s just a big, fat hoax,” says Dr. Hjort.
Hi Camille, PMS is very challenging no matter what age. PMS is estrogen dominance issues and boosting progesterone is very helpful for this. You might also consider Magdalena’s Herbs for Balance program that will go into this issue much more in depth. http://www.herbsforbalance.com/join. Think about liver health and metabolizing estrogen better. See this article about the topic. https://hormonesbalance.com/articles/what-is-estrogen-dominance-as-a-hormonal-imbalance-in-women/. Hope that helps.
you are so right other symptoms are adreanal gland nodules adreanal gland removal plus miscarrage high blood pressure low pattassium as your cortrisol levels are effected cancers as nodules turn into tumours this happens in our babies too they are born with no progestrone because we dont have any darling we cant get pregnant and carry a babie because of this ether red meat sugar soya dairy all lower our progesterone levels your levels drop after ovulation so that the egg does not fertilize because of estrogen domanance we will ovulateokay though
I haven’t felt right since I had my baby (who just turned 2).  🙁  History:I had post partum, major stressors and major sleep deprivations.  Nursed for 13 months.  The pregnancy sugar cravings remained & were intense.  I felt like a robot for at least the first year. Def felt like I should be feeling more euphoria.  And over the course of that first year and a half, my weight decreased.  About 6 months ago or more, my appetite became very low, I had food aversions just like I did in pregnancy.  My platelets and Vit D were low but everything else checked out fine.  I have PMS, my cycles seem shorter and vary from 3-4 weeks.  For at least 2 months, I’ve had night hot flashes days before I start.  But the WORST symptoms are my heavy/foggy/fatigued head and hard to stay on task!!  Even after 8 hours of sleep.  Have not gotten my progesterone checked….some dr’s say it’s not worth it since it fluctuates.  1 was just going to put me on progesterone wo/ checking.  others say antidepressants. Thoughts?  
@Barbara, You’re right, taking a bio-identical hormone may negatively affect fertility when they are not needed. Progesterone can increase the chance of keeping a pregnancy in a woman who is chronically low. (to low progesterone and miscarriage is likely) And using some short term supplementation with progesterone can help a woman who is estrogen dominant.
But because estrogen helps eggs to mature, my thinking is that women who have to much (and still adequate amounts of progesterone) may ovulate within weeks/months after birth – much earlier than in the past. So I think that at least 12-18 months of lactation amenorrhea is very probable, sometimes extending beyond that. And “normal” hormones during breastfeeding should include enough prolactin to supress the progesterone production so that the body does not conceive while another baby is still relying on the mother for all of it’s nourishment.
Clomid, normally taken for five days at the beginning of the menstrual cycle, acts as both an estrogenic and anti-estrogenic drug. Clomid occupies estrogen receptors on the ovary, pituitary, hypothalamus and endometrial tissue. Clomid stimulates the release of gonadotropins, hormones that stimulate follicle development and egg maturation. Clomid not only induces ovulation in women who may not ovulate at all but also produces a "better" follicle. A more mature and well-developed follicle will produce a better corpus luteum, which may in turn produce more progesterone.

Once a diagnosis is made, our Homonal Infertility specialists can work with you to determine the course of treatment. Depending on the cause of homonal infertility, there are many options to offer an infertile couple. The types of treatments may include the following: medications, intrauterine insemination, surgery, assisted reproductive technology (ART), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), donor eggs, embryo cryopreservation, embryo adoption.
The cream is often not enough to substantially increase progesterone levels and a bioidentical pill or suppository is usually looked at then. The creams usually have applications that give you 10-30 mgs of progesterone, though it’s hard to tell how much is being absorbed. The pills/suppositories can range up to a couple hundred mgs, though I’d make sure to work on finding out the cause of the low progesterone as being on them long-term isn’t ideal. And some women do have side effects with the supplementation so it’s important to work with your doctor and take just what you need.
Progesterone is a hormone found in men, women and children. Everyone needs a small amount of progesterone for good health and longevity. Women of reproductive age need (and produce) the most. Progesterone plays an essential role in a woman's reproductive cycle and her ability to have children, and if she does not produce enough and has low progesterone many serious problems can occur.

However, some studies also point to the fact that if you have low progesterone, raising progesterone can help to alleviate some stress. A study published by the University of Michigan found that increasing progesterone helped to reduce stress in some cases. Women felt more inclined to help others and it was easier to bond with others. It was also noted that strong relationships can also help to increase progesterone.22
Normal Levels of HCG & Progesterone What Are the 5 Events of the Menstrual Cycle? Signs and Symptoms of a Low Progesterone Level Effects of Progesterone on the Uterine Lining Hormones to Help Get Pregnant What to Do If Progesterone Is Low During Early Pregnancy? High Testosterone & Pregnancy Side Effects of Mirena & Copper Coils Drugs That Help the Ovaries Release Eggs to Become Pregnant How to Try to Get Pregnant With One Ovary What Is an hCG Trigger Shot? Abnormal Estradiol Levels Femara Side Effects for Fertility Is Progesterone Supplementation With Birth Control Pills Safe? How to Have a Successful Pregnancy With Low HCG Symptoms of High Progesterone Reasons for Weight Loss After Failed IVF Benefits & Risks of Vitamin B-6 for Fertility What Is the Average HCG Level at 4 Weeks? Does Low Progesterone Cause No Pregnancy Signs?
Hello. I just found your site and feel hopeful in regards to what I am reading so far. I i’m 57 years old and had a total hysterectomy when I was only 34 and have been on Estrace pill all this time. I’m putting the pieces of the puzzle together regarding some health issues and I am wondering that not taking progesterone all this time is at the root of those problems. Would adding a progesterone cream to what I am presently taking (2mg milligrams of Estrace) be all I needed to balance things out?
Dr. Westin Childs is a Doctor of Osteopathic Medicine. He provides well-researched actionable information about hormone-related disorders and formulates supplements to treat these disorders. He is trained in Internal Medicine, Functional Medicine and Integrative Medicine. His focus is on managing thyroid disorders, weight loss resistance, and other sex hormone imbalances. You can read more about his own personal journey here.
I am suffering with pretty much all of the above. I have to have 2 rounds of IVF to have my first child and the second cycle was an Immune cycle which worked. I was diagnosed with Vit B12 B6 and Folic Acid deficiency and MTHR gene mutation. Also my natural killer cells were at about 33% instead of below 10%. I have only one tube but both ovaries. I know I ovulate from the side I have a tube as I feel it and I actually think I can get pregnant but my issues are completely around implantation. I had to use progesterone inject oils to sustain my last pregnancy. We are now TTC our second naturally…but not having much luck 3 years on. I have brown spotting 9 days after ovulation or a few days before period starts which I am putting down to low progesterone and this is usually followed by my period on Cycle Day 28. My menses are between 28-32 days. I have all of the symptoms listed above, definitely fatigue, brittle nails and cracked heels, mood swings and mid section weight gain. I also suffer with allergies and asthma. 
hmm.. This is interesting. I get confused about the relationship between progesterone and estrogen. I was diagnosed with low estrogen a little over a year ago, and I have like 90% of the symptoms above. It’s been difficult finding info on low estrogen (except for menopausal women, which I am not… I’m in my mid-twenties..), because I think it’s really unusual in this day and age for someone to have low estrogen instead of being estrogen dominant like most people. The test results said that whatever steroid it is that converts into estrogen was really high in my body, but for some reason my body just isn’t converting it like it should, which I attribute to my adrenal issues and my body just being too worn out to do it’s job. But are some of the symptoms for low progesterone the same and for low estrogen? Because I’ve read (and been told by my naturopath) that some of my symptoms like vaginal dryness, painful periods, and low sex drive are due to low estrogen. But then I seem to also have some symptoms of low progesterone (like short luteal phases). I’m confused!
Hi, i was diagnosed with depression and sent to a physchologist back in feb this year. I was always tired, moody, irrational, low to no libido, stressed, heavy periods,  pain in my lower abdomen, crying easily and a lot, unable to concentrate, no motivation to get stuff done. After a number of therapy sessions I was given the all clear in May. It was determined that my depression was a result of relationship issues. I’m 33years old have a 2year old son and work full time. Shortly after being diagnosed my fiancé   ended our relationship. In June I moved out with my son. I’m still getting all of the symptoms above now and my moodiness and irrational thoughts occur more during my period. I think my relationship problems were because of my symptoms above and I’m looking for reasons why I’m still having these issues when I’m no longer with my ex. I was reading the above symptoms and in my head going… Yep yep yep… Thinking I should get my hormone levels checked… What can I do to help if I do have low progesterone though?? 
Hi there, my progesterone levels are <1 my doctor thinks it is due to dieting and too much exercise, I have a low body fat 14% I was a runner but have stopped and only do weights now so very sedentary. I have upped my calories too but still haven't got my period. It has been overa year since I had my last period. I haven't dieted or done any running for over 4 months and I haven't had any change. What do u suggest?
A woman's ovaries may produce high progesterone levels. This hormone is naturally secreted during the second week of her period in a woman who is in child-bearing age. The substances are called progestogens or progestins. They are also found in birth-control pills, in hormones given during menopause for replacement therapy, or in medications to correct abnormal bleeding problems during menses. These hormones are also used to counteract PMS syndrome, infertility, and pregnancy loss. Many women are aware of the effects of too little or too much estrogen, but have never looked up progesterone side effects.
I just received test results back that have my progesterone at 47 (vs. 75-270 healthy) and my PG(?) ratio (progesterone to estrogen) at 28 (vs. 100-500 healthy). Clearly, there’s a problem. I got tested b/c my hair has fallen out like you cannot imagine. Scary. Almost bald. I want to use a natural progesterone cream ASAP to try to get the hair growth back but I had a transient ischemic attack (TIA) in 2007. Does that mean I really shouldn’t try a cream? Thank you so much for your GREAT site!
During the egg retrieval process, the cells that normally create progesterone after ovulation are removed along with the eggs. Progesterone supplements are then required to prepare the body for pregnancy and thicken the uterine lining to support successful embryo attachment in the womb. Progesterone may also be required during the pregnancy to safeguard against pregnancy loss. Continuation of progesterone supplementation is advisable, on an individual basis, even up to 12 weeks of pregnancy in a cycle where embryo transfer is done.
The ‘pill’ is often prescribed as the solution to reproductive disorders, yet it’s designed to attach the drug progestin (not progesterone) to the progesterone receptors to block the uptake of progesterone thus preventing ovulation. The problem is if we don’t ovulate we don’t produce progesterone. Balanced progesterone levels are essential for a healthy reproductive system.
Progesterone is essential for maintaining a pregnancy. It is responsible for increasing the vascularity of the endometrial lining and stabilizes the endometrium in preparation for embryo implantation. Progesterone also protects the embryo and fetus by interfering with natural killer cells during the first stages of pregnancy (source).   Additionally, progesterone may reduce risk of premature birth in some women. 
Hi Donielle. I was wondering if you think progesterone cream would be a good idea for someone like me whose progesterone levels, fsh, and tsh have all tested perfect but who continues to have brown light to medium spotting for 10 days before my period EVERY month. it’s quite frustrating. My doctor says my progesterone looks fine, but i cant help but think it must be dropping low at some point to give me this bleeding. I have a four year old, but have been having this problem for the last year ,and now that we are trying to get pregnant am having no luck. Thank you for all your info!

Progesterone is found in many different forms and can be taken either by mouth if you’re prescribed to take progesterone pills, by intramuscular injections if the doctor recommends you to mix progesterone with the oil, or through the skin, if you choose to use progesterone cream. Commonly, progesterone creams are considered to be more effective since they don’t get lost through the liver and quickly get absorbed through the skin. Still, this is where the rule “the more the better” isn’t applied, for if you use more cream than recommended, you can achieve an effect opposed to the desired one and cause hormone imbalance. The compounds with the oils used on different women may also lead to very opposite reactions, therefore, the medication should be prescribed individually and, as we’ve mentioned above, by a professional. We will take a closer look at the treatments, including those that can be done in a natural way, further in the article. For now, let’s identify the common symptoms that tell of the progesterone deficiency and learn some basic causes that lead to the hormone imbalance.


I have read that it can take from 3-6 months to clear from your body. There is some conflicting information about the best place to apply the cream. Sometimes it can build up in the fat in your skin. I haven’t tried it yet, still doing research, but putting it on the mucosal tissues outside of your vagina is supposed to be a better place to let it enter your bloodstream in a natural way. Thanks for your comment about the anxiety, this is the kind of stuff I’m reading about to see if it is a good choice for me.
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