Hai , Iam 29yrs old , got married 3yrs ago , since last year I am suffering with spotting for five days before my actual menstrual flow , my cycle is regular , is that due to progesterone deficiency, I am already on inferlity treatment since 4months , not yet conceived.. My gyno checked my prolactin levels bt not progesterone levels.. Please doctor suggest me something that I need to do… Will be waiting for ur answer…

Some research has found progesterone to be helpful and others have found no difference between the placebo groups and progesterone groups.  Some research supports progesterone to be helpful in certain cases such as multiple miscarriages, short luteal phase, in ART and for preventing preterm labor. Yet several questions remain about how effective progesterone is for different issues and there is still not a clear answer to whether synthetic versus natural progesterone is better.
Low progesterone levels can be caused by several known factors or unknown factors. Due to the complexity of hormones, some women may have no difficulty getting pregnant but for some reason, the placenta does not create the proper levels when it should. Researchers believe that high levels of stress, poor nutrition and lack of exercise can contribute to low progesterone levels. Certain medications can also interfere with the body’s ability to produce progesterone.
I have a lot of these symptoms. I haven’t been diagnosed for sure yet, but I believe that my body is being affected by low progesterone. Around day 4 of my cycle, I start getting depressed and it lasts about 3-4 days (day 6-7 of cycle being the worst). My mood seems to start improving on day 8 with it back to normal by day 9-10.  My face has also been breaking out, I’ve been tired at different times of my cycle, and I have virtually no libido.  This has all started happening since I stopped the pill (Ortho cyclen) in August. 
Because of the lack of evidence for improved pregnancy outcomes, the ASRM Practice Committee Opinion does not advise luteal phase hormone therapy with HCG or progesterone unless you are undergoing an assisted reproductive technology (ART) procedure, such as in vitro fertilization (IVF). Pituitary suppression drugs used during ART cycles can interfere with corpus luteum function and progesterone production. In this situation, treatment increases pregnancy rates and reduces miscarriages.
I am confused as to why I cannot seem to naturally heal myself…I eat only whole food. This includes plenty of healthy fats from grass-fed beef tallow, dairy, and bone broths, soy-free pastured eggs, organically grown vegetables (fresh from the farmer’s market), and meats from grass-finished beef and lamb. I eat fatty fish at least once a week and also avoid vegetable oils (and other polyunsaturated fats). I do not consume any sugar and probably only eat about 20% of calories from carbohydrates. Could this be the issue and is supplementation with a progesterone cream the only hope? If so, is using cream a temporary treatment until progesterone levels are regulated or is this a life-long treatment?
I’ve got a question… I had a miscarriage in ’05. Then had a very healthy pregnancy in ’08. Since then this past Feb we tried again and I suffered a horrible miscarriage. Last month I had yet another, luckily this one was quick and my body actually took care of it all. If I have low progesterone, could this cause the miscarriages? And if so, should I be tested for this before we try to conceive again?
Dr. Hotze: They can’t patent it. Can’t make any money on it. The other thing that can cause migraines, by the way, is food allergies. Common foods: wheat, corn, egg, milk, yeast, and soybean are the big six, but any food can cause food allergies. One of the food allergies, very commonly, is migraine headaches. So, if progesterone doesn’t solve the problem or magnesium, it may be a food allergy on that.
I’m so sorry about your previous miscarriages. Low progesterone is only one cause of a miscarriage – though I wish this were easier for me to answer. While I can’t offer you direct advice, I can tell you that when miscarriages are not understood, many doctors will opt to prescribe progesterone preventatively, in the hopes that it helps to maintain a pregnancy. Please let me know how things go. Warmly, Dr Julie

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Hello. I just found your site and feel hopeful in regards to what I am reading so far. I i’m 57 years old and had a total hysterectomy when I was only 34 and have been on Estrace pill all this time. I’m putting the pieces of the puzzle together regarding some health issues and I am wondering that not taking progesterone all this time is at the root of those problems. Would adding a progesterone cream to what I am presently taking (2mg milligrams of Estrace) be all I needed to balance things out?
No one test result can determine is a woman has unhealthy amounts of progesterin. The hormone increases and decreases through numerous factors, such as age, test method, and the procedures of different labs. Also important is to know where the woman is in her menstrual cycle since the amount of the horome will change with the time of the month. There is more of the chemical when the egg is released from the ovary. The amount continues to rise if a pregnancy occurs or falls if menstruation begins. That's why serial measurements will be taken. Therefore, a woman will undergo numerous tests to determine what her cycle is doing.
Sometimes, the tests are not done in the best way to show the clearest picture. Magdalena has this talk about testing https://youtu.be/tpitbCA1yXg. Also, you will want to catch this workshop to learn more http://www.cookingforbalance.com. When we have too much of the toxic aggressive estrogen it “pushes down” the progesterone. So, the trick can often mean resolving the estrogen dominance. ~Deanna HB Team
Progesterone is commonly prescribed to women who experience multiple miscarriages, have signs of having a short luteal phase and those who are receiving artificial reproductive technology (ART) treatments. Progesterone treatment, however, is controversial and the medical community still has a lot to learn about progesterone, including how to test for deficiencies and what side effects there may be.
When I was pregnant was the first time Ive ever felt emotionally stable.  It makes me wonder if I normally have a progesterone deficiency. I’m normally moody, reactive, anxious , depressed, overweight, crave sugar, have dry skin, brittle nails and thin hair. I lost 20 pounds while pregnant and didn’t have the same cravings I do when not pregnant.  My husband even said I’m much nicer when I’m pregnant! How do I know if I indeed have a hormone imbalance? I had my thyroid levels tested two years ago and they were normal. I’m about to start taking the mini-pill for birth control, could this help balance things out? 
I noticed changes in my body throughout my pregnancy last year (obviously), from negative skin changes and hormone changes. During pregnancy I was highly stressed and undergoing circumstantial depression. As a single mom and only parent to my child, I have dealt with a lot of stress and loneliness, especially after a death in the family just after my child was born. The changes since pregnancy have worsened. Despite daily vitamins my skin has become dry and splotchy and my nails similarly dry. Though I’m prone to bouts of sadness I mainly struggle with anxiety, stress, and mood swings leaning towards anger that drive me to be hermit-like, especially combined with the fatigue and fogginess of mind I though was only a post-partum symptom. I have also since dealt with inconsistent menstrual cycles (though birth control has helped somewhat). Like I said, I had thought some of these symptoms the product of post-partum and the hormonal rollercoaster due to circumstance. I have sought medical help for the fatigue and foggy thinking (it is so severe that I struggle with my job). Though I am only in my 20’s should I bring up to the topic of possible low progesterone to my doctor?
At this point, patients are told they have a hormonal imbalance and will need natural hormone replacement that can include estrogen, progesterone, and sometimes also testosterone. Typically, patients are also given thyroid support, vitamin C, vitamin B, glandulars, herbs, DHEA and pregnenolone at the same time. Such a multi-hormone approach is designed to replace diminishing hormones the body may be experiencing. The key to success or failure of such an approach lies largely in the dosage and delivery system of the hormone replacement. Some doctors tend to be quite aggressive, while others are more conservative.
I haven’t felt right since I had my baby (who just turned 2).  🙁  History:I had post partum, major stressors and major sleep deprivations.  Nursed for 13 months.  The pregnancy sugar cravings remained & were intense.  I felt like a robot for at least the first year. Def felt like I should be feeling more euphoria.  And over the course of that first year and a half, my weight decreased.  About 6 months ago or more, my appetite became very low, I had food aversions just like I did in pregnancy.  My platelets and Vit D were low but everything else checked out fine.  I have PMS, my cycles seem shorter and vary from 3-4 weeks.  For at least 2 months, I’ve had night hot flashes days before I start.  But the WORST symptoms are my heavy/foggy/fatigued head and hard to stay on task!!  Even after 8 hours of sleep.  Have not gotten my progesterone checked….some dr’s say it’s not worth it since it fluctuates.  1 was just going to put me on progesterone wo/ checking.  others say antidepressants. Thoughts?  
I miscarried my first pregnancy in April 2013 at 8 weeks. I started charting in June, which indicates luteal phases of 9, 10, 11 and 13 days. I suspect low progesterone is part of the problem even though I am of healthy weight, active, eat well, etc. You mention getting testing done, but can you name the specific tests and the time during my cycle the testing should be done? Thanks!
Contraceptives - so many woman fail to ovulate when they stop using contraceptives.  As they are designed to stop ovulation, they can cause temporary infertility.  Initially the ovaries make estrogen and testosterone, but it can take a few cycles later before the ovaries start ovulating. A severe imbalance takes place in the ovaries if the level of estrogen and testosterone is too high.  Supplementing with progesterone with regulate the cycle.
You’ll also need to rest (you read that right).  Remember earlier how we said that running around without time to rest and reflect can lead to poor food choices?  Beyond poor food choices, it can lead to poor life choices!  So take some time each day to let your mind unwind.  You can read a book, journal, meditate, nap…whatever you like.  It’s great to occasionally take a retreat in a natural setting too. Make sure to get a good night’s sleep each night, as critical healing and rebuilding happens nightly.
Stacey B: Well, Dr. Hotze, thank you for being such a visionary, too, and recognizing years ago the positive impact it would have on women. Now you know why I was so excited at the beginning of this podcast about the benefits of progesterone. It’s so easy. If you’re out there thinking, “Do I have symptoms of low progesterone? Would that be able to help me?” So easy to go to our website HotzeHWC.com. That’s H, O, T, Z, E, H, W, C.com and take our symptom checker. Then you can also call our office for a free consultation at 281-698-8698, as well. It’s a pleasure having you here today. We are so glad you joined us today here at Dr. Hotze’s Wellness Revolution.

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Progesterone levels fluctuate throughout your menstrual cycle. Your numbers rise each month during the second half of the menstrual cycle, about seven days before your period. That's because one of this hormone's most important functions is to cause the uterine lining to secrete special proteins to prepare it for an implanted fertilized egg. If the lining isn't thick enough, implantation won't happen.
As we learned earlier a leaky gut (increased intestinal permeability), can increase your odds of autoimmune diseases.  It can also decrease your odds of get nutrition out of your foods.  So your digestive system is important to heal and maintain.  Do this by eating a wide variety of plant fibers- aim for twenty different types a week- to feed your friendly gut flora. 
I have low progesterone as well as my 3 sisters. However I did not need progesterone to fall pregnant with my now 18 month old boy. My sisters and I all went through the saga of convincing our doctors this was the issue. I was on the max dose of progesterone suppositories through my entire pregnancy and although at one point it looked like my body was building its own supply I continued on with the suppositories. All I can say is trust your instincts. Too much Progesterone is not really an issue, so go with what you feel is right and don't let your doctor persuade you otherwise.
During the first half of your cycle estrogen stimulates the lining of the uterus to grow, but that leaves the job only half finished. In the second half of your cycle after you ovulate, your progesterone levels shoot up and help the uterine lining to mature. Progesterone stimulates the uterine lining to secrete important nutrients that are necessary to support the life of a growing embryo.
The Progesterone therapy depends on the stage at which the therapy has been prescribed at. It involves several cycles and dosages to improve the hormonal imbalances. It can either be in the form of intramuscular injections or through other modes. The natural mode of improving the hormonal imbalances can include consuming food rich in zinc, selenium, and magnesium. Take vitamin supplements and herbal medicines are a few other modes of natural treatment options you can opt for.
Progesterone is not a "feminising" hormone. That reputation belongs to estrogen. Excess estrogen or estrogen-imitators (including many pollutants in the environment) cause a variety of health problems for both men and women. Progesterone is a natural antagonist to estrogen. Progesterone helps to balance and neutralise the powerful effects of excess estrogen in both men and women. Without sufficient progesterone in the body, estrogen becomes harmful and out of control (unopposed estrogen or estrogen dominance).

Thanks for the great article! I had some postpartum issues after my first baby (mainly anxiety). My son is now a year and a half and I’ve been struggling with irregular periods since his birth. My functional medicine dr put me on bioidentical progesterone cream but my levels are still not very high. I will be regular for months and then have two periods within the same month. I take the cream throughout the entire month. I also take vitex and holy basil. Any other suggestions or thoughts? I’ve thought too about only taking the cream after ovulation and until my period but not sure! I’m 29 and prior to pregnancy never had any issues with my periods. Thanks in advance!
If you find that it takes a bit more energy to keep your cool or that you are no longer sleeping through the night I encourage you to look to progesterone as a way to help.   You can go to www.www.drtami.com and take a free hormone quiz to see where you might lie and what you can do with nutrition, supplements and lifestyle changes to feel even better.
Great article! I am 41 (not pre-menopausal) and have been experiencing all of those symptoms with the exception of infertility (that I am aware of) for a while. I also have mid cycle menstrual cramps with no bleeding. I have hypothyroid and take 90mg Armour Thyroid and just added T3 to that regime. My progesterone and cortisol was tested. Progesterone was low and cortisol was around 1250 at 10pm at night. The combination of underactive thyroid and high levels of stress have very negatively affected my energy, mental acuity, metabolism, ability to loose weight, anxiety and mood. I am curious why my ND gave me progesterone for 14 days only starting 2 weeks after the first day of bleeding. Why not all month if I am feeling like this?
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A low progesterone treatment usually consists of several cycles and involves a hormone therapy for improving the balance of estrogen and progesterone levels in women. Women needing the aid during the first trimester of pregnancy are often prescribed intramuscular injections which are typically made by mixing progesterone with one of the following oils: Ethyl Oleate, Olive Oil, Sesame Oil, Peanut and Cottonseed Oils. The compounds with these oils vary by thickness and the way they are absorbed into the muscle. Interestingly enough, the feedback from different women shows that different oils affect them differently and often result in very opposite reactions. Progesterone oils can also be massaged into the skin.
Hi !! So glad to read this. I have been irregular in my periods since I was 16. I am now 34 and have two children. My first pregnancy was very tough as I bled often and had low progesterone. My doctor put me on progesterone until I was in the clear at about 13 weeks. Same with my second pregnancy. A few months ago I started getting terrible panic attacks and anxiety. I always have brain fogs and I am extremely forgetful. My doctor referred me to a psychiatrist and therapist and that was that. They put me on Lexapro. I am doing very well on it but I still have little mood swings and still no normal period. I am so frustrated because for many years, my fight to figure out what is wrong, has failed. No doctor has ever looked into why I have never had a normal period. I feel like this article gave me some insight. Thank you !
Use a natural progesterone skin cream, not drops or pills. Progesterone is poorly absorbed when taken orally, being broken down by the liver and gut and excreted instead of being bio-available for use in the body. 95% of progesterone taken orally as tablets or drops is lost. (23) Progesterone is well absorbed transdermally (through the skin), and using it as a cream on the skin is the most effective method to take it.
Progesterone is made from the cells that surrounded the egg during its development. They are called granulosa cells. The cells make up the wall of the cyst that contains the egg. This type of cyst is called a follicle. As the egg develops, the follicle grows and the granulosa cells increase in size and number. Before ovulation (release of the egg), these cells produce mostly estrogen. After ovulation, they still produce some estrogen but a lot more progesterone. After ovulation, the follicle cyst is called a corpus luteum cyst.

As a result of its critical functions in the nervous system, progesterone has been classified as a “neurosteroid”. It is so essential that it comes from two different places to reach the brain: first, cells in the brain, spinal cord, and peripheral nervous system all synthesize progesterone from cholesterol.  Secondly, progesterone that is circulating in the bloodstream also has direct access to the brain and nerves.
Estrogen dominance occurs whenever a woman produces too much estrogen relative to her progesterone levels. Estrogen dominance can occur during perimenopause or menopause, but is becoming more prevalent among women of childbearing age. Excess body fat, chronic stress, and a diet high in sugar and processed starchy carbs can contribute to blood sugar imbalance and hormone dysregulation. When progesterone is low due to estrogen dominance, you’ll likely experience other symptoms like fluid retention, breast tenderness, and irritability.

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Stress - is also a major concern.  It drops progesterone levels and raises cortisol levels which are both signs of infertility.  The adrenals produce progesterone before converting it into cortisol.  If the adrenals are exhausted, they will find other sources of progesterone, normally ovarian.  This impacts on the reproductive cycle.  Stress can also cause anovulation and miscarriages.  Progesterone is excellent for stress as it activates the GABA receptor sites.  GABA is one of the most calming neurotransmitters.
Hi Donielle. I was wondering if you think progesterone cream would be a good idea for someone like me whose progesterone levels, fsh, and tsh have all tested perfect but who continues to have brown light to medium spotting for 10 days before my period EVERY month. it’s quite frustrating. My doctor says my progesterone looks fine, but i cant help but think it must be dropping low at some point to give me this bleeding. I have a four year old, but have been having this problem for the last year ,and now that we are trying to get pregnant am having no luck. Thank you for all your info!
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Signs of a miscarriage might be a heavier period, clots and/or pain. The egg takes about 12-14 days to reach the uterus, if the corpus luteum does not maintain a high level of progesterone during this time, menstruation will take place before the egg is embedded.  This can be easily corrected by supplementing with progesterone thereby extending the luteal phase.

Progesterone levels fluctuate throughout your menstrual cycle. Your numbers rise each month during the second half of the menstrual cycle, about seven days before your period. That's because one of this hormone's most important functions is to cause the uterine lining to secrete special proteins to prepare it for an implanted fertilized egg. If the lining isn't thick enough, implantation won't happen.


I was actually diagnosed as infertile due to a lack of ovulation…. which I decided on my own was wrong. I’m an herbalist, so I’ve spent the past 7 years intensively studying the herbs used for hormonal balance both because I so desperately wanted to have children… and I think ultimately I was meant to share my journey. At any rate, what I found out on my own once away from the doctors was that I had a progesterone deficiency… I suspect this is a hormonal imbalance that can start in the womb, so it might be interesting to take a look at your mom and grandma if you still can. A big tip off for me, besides the short luteal phase was the brown discharge that occurred in my monthly flow. Ironically, I always thought that was normal because my mother had always had it as well. It’s a big sign that your progesterone is not sufficient to fully flush your uterine lining the month before and your womb is just constantly trying to get rid of left over blood each succeeding month. My mom also had a number of miscarriages and I was the only pregnancy to go full term. What’s great about this little symptom is that as I achieved balance, I could very clearly see a different cycle- one that was red from end to end. After a couple years working with the herbs (and a whole foods diet of course) I had my first child… and then I got pregnant by surprise about 18months afterwards! I believe I can see some symptoms of my chronic low levels returning- though my cycle remains red… so I’m going to have to start back into my routine.
Oh, I also have (especially lately) stupid bad sugar cravings and have been really fatigued. My memory kind of quit on me back when I was 17.  Every dr I have tried to go to until now, and currently this dr is a holistic ms, has insisted on putting me on a low dose anti depressant. Ok if it is major depressive disorder or bi-polar and I have to, then fine, but no one would do any kind of tests to see if I had an actual reason for the depression symptoms! 

If you have problems conceiving, there are many possible causes for your infertility. Low progesterone levels have different symptoms, but, many times, they are common to those of other medical conditions. Some of the symptoms of low progesterone are appetite changes, depression, mood swings, anxiety, irritability, weight changes, fatigue, irregular menstruation, headaches, low sex drive, painful intercourse, vaginal dryness, polycystic ovarian syndrome, lack of concentration and insomnia. Most of the times, women do not suspect low progesterone levels until they encounter infertility issues. Testing remains the most accurate way of diagnosing low progesterone levels.
I just recently had my progesterone levels and my t4 checked. I had my blood work done the day after, the last day of my period.  The readings were .4. My thyroxine/ t4 was 13.4, and my tsh was 1.170. I have had so many symptoms and it seems like my Dr. Isnt taking any of it seriously. I am not even sure what all of it means, but from what i have found it’s  not great, what should I do?
Nikki has a 4-year-old daughter and a 15-month-old son, and they are hoping for another in the future. In between the two she had been pregnant with a baby girl and went into preterm labor at 21 weeks. The little girl delivered very prematurely but soon thereafter developed a brain bleed. Nikki and her husband made the difficult decision to let her go peacefully.
I have hashimotos and hypothyroid. My cycle is clock work every 26 days, no biggie…. wrong! I bleed for 7-10 days and my iron levels won’t come up!!! I have been reading a lot of magnesium with my thyroid. Any suggestions on test? I was put on a progestrone cream based on my symptoms but I swear it was making me anxious unless it’s these winter months. So I’m going to hold off for now. But I wasn’t tested!?!?!
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