When we got “the talk” about periods, sex, and baby making, most of us learned what happens without much understanding of how it happens. Yet more women than ever are looking for answers about irregular or painful periods, trouble conceiving, or carrying a baby to term. In all of these issues, one common denominator keeps coming to the fore: progesterone. 

Nikki didn’t know if her DHEA levels had changed, but I suspect that they had. DHEA levels improve as a result of balanced cortisol due to improved adrenal function, we believe. That would create a more natural hormone balance on Nikki’s body as she was running heavily on cortisol due to the emotional stress from the death of her newborn, the miscarriages, as well as her ongoing concerns.
Sounds like you’re doing the right things, especially paying attention to your progesterone and estrogen levels. I’d personally give it a little more time to see if it works itself out on its own — menopause can do some interesting things when it starts cropping up (and 48 is a perfectly normal age for that to happen). On the other hand, you may want to explore whether or not you have any kinds of cysts or fibroids, which can cause long-term bleeding, with your doctor if these symptoms persist.

I have a question — I’ve been struggling with what I’ve been told is Hypothalamic Amenorrhea for a few years now. I’ve lost and regained my period several times due to fluctuations in weight, calorie intake, and exercise, but have always managed to get it back by changing my lifestyle. I had my period in January 2012, then didn’t get it again for an entire year. My gyno did bloodwork which was normal, except for low hormone levels (also had an ultrasound to check for cysts on my ovaries, result was negative.) In November of last year I took provera and had a withdrawal bleed, but no period in December. I then got my period this January (same time that I did last year, while I was on winter break from school) after further reducing my exercise, mainly cutting back on running. However, I haven’t gotten another period since.
Unfortunately, for most this honeymoon does not last indefinitely. While some people continue to do well on such a program, many report this multiple hormone replacement approach gradually loses effectiveness over time. Those who are already in advanced stages of adrenal fatigue prior to beginning such program are particularly vulnerable. Over months or years, there is a slow but gradual loss of the positive clinical outcome as compared to the initial benefit. As time progresses, many return to their doctor for more help.
Hey I’m 25 I’ve had cysts on my ovaries and have some pretty bad problems with them since I was 15 and have been battling with drs. Since. I finally have caught one drs attention.  I can’t have sex cause it hurts very bad some times I turn wrong it will hurt. But the last time I went to the Dr he told me I have to much progesterone and he wanted to try the pill. But it seems like from reading your article I have way more symptoms of it being to low Rather than having to much.  I have no children. And it makes more since why I haven’t been able to have one. I have terrible periods. Sometimes can’t even walk cause I’m in so much pain. And I bleed a lot more blood than most girls I’ve talked to anyway. And according to my period calendar ovulation happends 4 days after my period idk how accurate that is but it’s accurate about my periods for the most part. Idk I’m just tired of dealing with this and being as tho our drs are known for not doing there job well I was wanting someone else’s opinion. 
The Natural Hormones website suggests that progesterone levels may fluctuate during the course of a woman’s normal menstrual cycle, and low progesterone levels are common during the follicular phase of the menstrual cycle. Women with low progesterone levels may suffer from estrogen dominance. Psychological symptoms of low progesterone levels in women include anxiety, irritability and mood swings. Physical symptoms of low progesterone in women include headaches and premenstrual syndrome.

lastly, I started working out again finally (had been way too tired / no energy to do so before) about 2 months ago.   In an effort to gain weight, eat healthy again and feel better.   I have started gaining weight and my food appetite is back and no more sugar cravings.  However….the fatigue, foggy headedness, can’t concentrate, and a few days even blah or down…….I want that to go away!!!  Thanks!!!  
I am not sure what to do anymore, I have suffered with heavy periods and several miscarriages all of my adult life. I have also have had several myomectomies, all fibroids were benign, I am 45 and I have two children. I feel that after having my last child at 35, my hormones just turned on me. I started gaining weight and I was tired all the time, I was told by my doctor for years that diet and exercise was the cure. I was even put on phentermine and still gained weight, I suffered with depression, given medication for that. This yo-yo went on for years, I know working as a night nurse my body clock was always trying to keep up. Last year I started hormone treatment, I was diagnosed with Hashimoto’s and PCOS, I was put on bioidentical hormones, including thyroid medication. I was taking 60 mcg of thyroid along with 30 mg of testosterone, 200 mg of progesterone capsules, metformin 1000mg, spironolactone 100mg. I was feeling like a brand new person! As you mentioned above, it was short lived, the doctor wanted me to stop my anti-depressant medication completely, which is easier said then done, she also suggested I try a copper IUD. This type of therapy is not only expensive, but the medication is not covered by insurance because it is not approved by the FDA, I did not mind at first because I felt I had found my cure for my constant fatigue and weight gain. Well almost a year later I have gained 20 more pounds and no answer for my weight gain, I went back to my primary doc, who changed me to regular Synthroid and to eat ONLY meat and veggies along with walking two miles a day or more. I have all but given up, I know everyone reacts differently to medications, but those who suffer are ignored and left to not only to remain miserable, but to figure it out alone.

I had two miscarriages in a row, no live pregnancies. I was wondering ,was progesterone the culprit behind my loss. I gained nearly 10 kg by 14 weeks, without much eating. Also I had many episodes of very low blood sugar. My cycle is always regular 26 to 28 days. My uterus and ovaries are normal. But, both times growth of fetus stopped at 6 weeks.  Whatz your opinion??


I am 41 and seem to have all the symptoms of low progesterone. I have had 5 miscarriages which now sound like they could have been because of low progesterone, which nobody was able to tell me after all the bloodwork under the sun! I gave up the idea of another child and I was sterilised about a year ago because i didnt want to take any chemical forms of birth control due to my mother’s breast cancer (which she subsequently died from) was the kind of cancer which feeds on estrogen. So i have this 7 day spotting before a period which the gynae said she could give me pills for but I’m terrified of taking chemicals because i dont want to get or encourage the same kind of cancer…what can i do? (Live in Sunny South Africa so Vit D levels are high!)

I have all of these symptoms. However it isnt my hands or feet its my lips. 🙁  and the weight gain has been very rapid in my hips.  Once progesterone levels are regulated.. please tell me the weight comes off as rapidly as it came off.  I work out 5 days a week for 90 to 120 minutes.. split intervals of course.  1 day of yoga and one day of rest.  And i am so careful with what i eat.  The weight gain is making the mood swings worse because i hate myself for pushing to keep the weight off.. and it just seems to be coming back faster.


Hi Kylee! I’m so sorry you’ve had to deal with these symptoms and aren’t having much luck with a diagnosis from your family doctor. It might be worth a second opinion if you are keen to get to the root cause of your symptoms and have your progesterone levels re-examined. In some areas, there are nurses who also provide hormone balancing and support. You might want to ask around. Please keep me posted with your progress.
Cruciferous vegetables are a great way to reduce Estrogen Dominance. They are rich in glucosinolates, which activate phase 2 detoxification in the liver, helping to filter estrogen metabolites from your body. This is good news for your hormone balance because it prevents estrogen byproducts circulating for too long, which can raise estrogen levels and cause hormonal havoc.
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