As a matter of fact, I would say at the Hotze Health & Wellness Center, we really built our health and wellness center, I’d say what really grew it, were two key ingredients and that was natural progesterone. When I started giving that back in 1996, it transformed women and they loved it. It just changed their lives. The other thing was natural thyroid. So, those two components have been a huge part of building the practice. So, if you’re not on natural progesterone and you’re suffering from any of these symptoms of difficulty thinking, poor sleep patterns, weight gain, you’ve got fatigue, you’ve got body muscle aches, you’ve got irregular periods, you’ve got fibroids, you’ve got fibrocystic breast disease, you’ve had infertility problems, migraine headaches, you’ve got osteoporosis, any number of different problems. If you have these it may be that a tincture, a little progesterone, could go a long way to helping restore you to your health and wellness.

Also please stay away from all scented lotions and laundry detergents, air fresheners, cleaners etc….The chemicals can can caus estrogen dominance flare ups! I love unscented micellar water wipes to moisturize with. Or an unscented oil in the shower works well for especially dry areas but don’t slater from head to toe…your skin needs to breath. These fragrenced products are proven to cause endocrine disruption and once I cut them all out as much as possible I noticed a HUGE difference.
I have always been very healthy and have gotten pregnant very easily. The year I turned 30 I had my first miscarriage, followed by 3 more within 2 years. All of the miscarried babies measured between 8-12 weeks. After the miscarriages I experienced stress, anxiety, depression, headaches and dizziness over the year. This was followed by the classic symptoms of low progesterone–in fact, my doctor thought my symptoms were much like menopause. My hormones were tested 2 weeks apart and both showed very low progesterone. My questions now are twofold: 1) What is the cause of my low progesterone? And 2) Is it important to keep my progesterone up? My doctors have seemed to only want to do something if I feel like I need it. I have acne, low libido, foggy thinking, joint pain, and no menstrual cycle, all moderately. I hesitate to do hormone therapy because I do not want to experience the depression/anxiety again. Any thoughts?
A lot of these symptoms listed and many ongoing complaints are signs of hypothyroidism, specifically Hashimoto’s. I urge anyone who has ongoing hair loss, weight gain, and some other 300+ symptoms (Google 300 symptoms of hypothyroid) to have their TPO and TgAB antibodies checked.  Even if your doctor has checked the TSH and says “you’re  fine”.  The antibodies will show up way before the TSH numbers do, and yet a person will still be symptomatic. There are also dietary changes that can help ease symptoms.  There are so many overlapping symptoms for so many conditions, just wanted to throw this info out there in hopes it is helpful to someone.  I wish I had this info 5 years ago. It would’ve been a game changer for me.  Happy trails and happy hunting!!!
I have hashimotos and hypothyroid. My cycle is clock work every 26 days, no biggie…. wrong! I bleed for 7-10 days and my iron levels won’t come up!!! I have been reading a lot of magnesium with my thyroid. Any suggestions on test? I was put on a progestrone cream based on my symptoms but I swear it was making me anxious unless it’s these winter months. So I’m going to hold off for now. But I wasn’t tested!?!?!
Hi, I’ve just been diagnosed with low progesterone after having the majority of these symptoms. At first I blamed it on coming off the pill last October but as time has gone on and no signs of pregnancy I knew something wasn’t right. I now have been referred on to the fertility clinic to see if I can balance it out! Feel relieved after reading this artical that I’m not the only one! Thanks 

I have a question. I’m forty one and the Dr. Put me on Progestrone to shed the lining every month since I might twice a year. He put me on progestrone since those levels were low and try to force my body. He said if the lining is not shed every two or three months it could make a bed for cancer cells to grow. Still no lining shed. Is this common knowledge?
Abnormal thickening of the endometrium (endometrial hyperplasia). Some research suggests that applying progesterone (Crinone) into the vagina prevents endometrial hyperplasia in women with an intact uterus that are taking estrogen replacement therapy. Other early research shows that a specific intravaginal progesterone cream may help reverse abnormal thickening of the endometrium and decrease vaginal bleeding in premenopausal women with non-cancerous endometrial hyperplasia.

In some severe cases, the PMS or premenstrual syndromes can even cause advanced stages of disorders. The low levels of Progesterone have an effect on the neurotransmitters in your brain and thus can result in mood swings and depression. Though mood swings are general symptoms during menstruation, a high intensity of these occurrences can indicate low Progesterone levels.
9. Take care of your adrenal glands and lower stress evels. When your endocrine system is on high alert due to stress of some kind (frequent physical, emotional, or mental stress) the precursor hormone to progesterone (DHEA) is then used to make cortisol instead of progesterone. A 24-hour adrenal saliva test can show you what your cortisol levels are throughout the day and may be helpful in helping you heal the body. Working to reduce stress allows the body to come out of its fight or flight response and begin using its hormones for reproduction.
I have many of these symptoms, I am currently on BHRT and take a topical estrogen and Rapid Dissolve Tab of Progesterone for 4 years now after a hysterectomy with one ovary removed… Throwing me into a downward spiral into Menopause. Yikes!! and I am still experiencing some symptoms of imbalance. I have mentioned this to my Physician and he always looks at my labs and tells me I am at a good range. I am getting frustrated with the continued symptoms, he is a highly trained bioidentical hormone doctor. Not sure what the answer is at this point. Not too many  bio doctors to trust in my area. 
Progesterone may affect the skin and some patients may experience increased acne. Patients may aldo experience a rash at the site of the injection. Progesterone can also cause skin discoloration and seborrhea. Progesterone may affect your vision, causing blurred vision and other vision changes. Progesterone can affect your mental state and 19 percent of patients experience depression. Patients may also experience anxiety, insomnia and impaired concentration.

To add: Generally I'm very laid back and I eat decently well. I'm the right weight, exercise well and am happy. However, right now I'm going through one of the most emotional times of my life. My horse (whom I've had since I was a pre-teen) is failing and is going to be put down in the next few weeks. So, yes, my emotional state is less than ideal right now. However, these m/c were both very similar and one happened well before my boy was sick. That leads me to believe it did not cause the m/c.
Coutinho, Walmir, Appolinário, José C., Póvoa, Luiz C., and Meirelles, Ricardo. Terapia hormonal e os sintomas psíquicos na menopausa. Parte 2--Estudo duplo-cego dos efeitos da progesterona natural sobre os sintomas psíquicos da menopausa. = Hormonal therapy and the psychiatric symptoms in menopause: II. Double-blind study on the effects of natural progesterone on the affective symptoms in menopause.. Jornal Brasileiro de Psiquiatria 1995;Vol 44(5),pp. 223-229.

Autoimmune Hashimoto’s Thyroiditis is the leading cause of hypothyroidism. The gut, as we discussed in the Poor Nutrition section and will discuss again in the closing section, is a key area of focus in healing Hashimoto’s.  When peptides (parts of the protein in foods) cross the gut barrier into the blood stream it stresses the system and the immune system responds by going after those peptides that shouldn’t be there.  But the trouble is that this dysregulated immune system will also attack the body’s own tissue, in this case the thyroid gland.
This was posted a while ago but I was just curious. How serious can low progesterone be? A few years ago I was trying to get pregnant and after almost a year and tons of research I decided I should see my GYN since I had irregular/infrequent periods. She tested my hormone levels and told me low progesterone was the reason I was having issues getting pregnant or even having a period. She gave me clomid (sp?) to make me ovulate and I did become pregnant that month I took it and had a beautiful little girl. My concern… she acted like it was nothing, helped me get pregnant, and that was that. I have maybe 4 periods a year and I’ve been that way since my first when I was 12. After my baby I had regular periods for a few months then back to my normal irregular periods. Is there something that causes progesterone to be low? Should I be taking birth control to make my cycle normal?
Ludwig, M., Finas, A., Katalinic, A., Strik, D., Kowalcek, I., Schwartz, P., Felberbaum, R., Kupker, W., Schopper, B., Al-Hasani, S., and Diedrich, K. Prospective, randomized study to evaluate the success rates using hCG, vaginal progesterone or a combination of both for luteal phase support. Acta Obstet.Gynecol.Scand. 2001;80(6):574-582. View abstract.
A: Hormone replacements, such as Prometrium (progesterone) can be useful during menopause to relieve symptoms of hot flashes, vaginal dryness, and sleep disturbances, but there are risks that come with them. Studies have shown an increased risk of breast cancer, heart disease, and stroke when using female hormones. Prometrium 200 mg has been approved by the FDA and is usually given as a single dose at bedtime for 12 days sequentially per 28-day cycle, to postmenopausal women with a uterus who are also taking estrogen tablets. In other cases, 400 mg is given nightly for 10 days. It is given to prevent estrogen from thickening the lining of the uterus, which could result in a higher risk for uterine cancer. Common side effects may include headache, breast tenderness or pain, upset stomach, vomiting, diarrhea, constipation, tiredness, muscle, joint, or bone pain, mood swings, irritability, excessive worrying, runny nose, sneezing, cough, vaginal discharge, and problem urinating. Hormone replacement therapy is not meant to be taken on a permanent basis. After the symptoms of menopause are gone, the hormones should be stopped, due the their risks. Some women do not experience symptoms of menopause, and if you do not have problems with symptoms, you probably do not need to be taking the hormones. Factors that influence menopause and how long it will last include genetics, lifestyle, diet, stress, general health, and cultural perspective. Some symptoms, such as vaginal dryness and urinary symptoms, may persist into postmenopause, but most diminish and disappear within 12 months of the last period. After that, your doctor may decide to discontinue the hormone treatment. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Patti Brown, PharmD
Dr. Hotze: As soon as they have the baby, the placenta’s delivered and there’s a precipitous drop of the hormones. Now the ovaries have to turn back on. They’ve been shut off for nine months or thereabouts and what happens then is that if they don’t turn back on and make the hormones, they might be sluggish in turning on. Then a woman can have a host of problems with fatigue. Can get the baby blues, as they call them. Postpartum depression. The next thing you know, some conventional doctor throws them on a bunch of antidepressants and begins to ruin their life. 
As for taking progesterone during the first trimester – sometimes I think it’s better safe than sorry. (though your levels sound really good!) If you do choose to go on progesterone, you may want to ask for a bio-identical progesterone and stay away from the the other stuff. From what I’ve heard from other women, most of the time the cream is sufficient, but when women really do need the boost because of low progesterone, most docs tend to go with suppositories. They can also do another lab to make sure it’s rising sufficiently.
@Bethany, I was told with each of my pregnancies (all five– I’ve only had one live birth so far) that my progesterone levels were low, usually right before I miscarried. With my third pregnancy and first live birth in fact, I was told that I was miscarrying because my levels were so low, but that they would put me on prog cream “just in case.” It wound up working for us that time, but the pills I was put on with my next pregnancy didn’t help at all.
Hi, I have just been through my second miscarriage. The first one was ectopic about 2 years ago. I was exercising excessively at the time, cardio and bodybuilding, my periods stopped months before I then started to bleed and get pains, went straight to A&E and was told I had an ectopic pregnancy, I didn’t need surgery, had an injection and I was fine after a few weeks. This time I do not exercise anything like I have in the past, my periods are quite heavy but regular, I conceived within 2 months of trying but miscarried at 6 weeks. My concern is that I have low progesterone. Before I conceived I’ve had dry skin mainly on legs and hands, swollen ankles when I sit for longer periods, heavier periods than normal with cramps, also weight gain but that may be down to less exercise. I was just wondering if my pregnancy losses may be down to low progesterone. Any advice would be helpful. Thanks. Xx
Women who experience an imbalance of hormones may experience symptoms of premenstrual disorder which over a prolonged period of time can lead to irregular menstrual cycles, tender breasts, endometriosis, fibroids, heavy menstrual bleeding, and other symptoms associated with low progesterone levels. Hormone replacement therapy can help to bring levels in balance so that the discomfort is diminished and cycles will become normal with minimal irritability. A doctor can prescribe a synthetic product or recommend a bioidentical source. A bioidentical hormone is made from plant sources so they closely resemble the natural hormones found in the body. These substances are also known as phytoestrogens and are found in soy products.
Men should use 10-100mg per day. This is suitable to treat symptoms of low progesterone, symptoms of low testosterone, or more commonly, symptoms of estrogen dominance caused by xenoestrogens. Vary the dose depending on the severity of the symptoms. The amount of progesterone to use is not dependent on your weight, size, height or age, but on your symptoms.

Donielle believes women can learn how to heal their bodies & balance their hormones through natural methods. An advocate for natural health, she has a passion for nourishing/real food nutrition and natural living. Her personal background includes both infertility and miscarriage and she started Natural Fertility and Wellness in 2008 in order to share all of the information she found helpful in her journey to heal from PCOS and overcome infertility.
Using a NaProTECHNOLOGY approach for the treatment of infertility can be highly effective and even more effective than current approaches to infertility.  In Figure 51-5, a life table comparison of the effectiveness of NaProTECHNOLOGY (in blue) with a similar non-NaProTECHNOLOGY approach taken at Johns Hopkins University is shown.  The success rates are clearly better using the NaProTECHNOLOGY approach.
There is no difference in pregnancy rates based on the level of progesterone at the midluteal phase. According to a 2015 American Society of Reproductive Medicine (ASRM) Practice Committee Opinion on luteal phase deficiency, in the absence of other abnormalities of the menstrual cycle, low progesterone in the luteal phase does not appear to affect fertility or reduce normal pregnancy rates. Instead, most failures of implantation, chemical pregnancies, nonviable fetuses, and other early losses are because of chromosomal abnormalities, ASRM concludes.
Please note that content on this website is intended for informational purposes only, and is not intended as a substitute for the advice provided by your physician or other healthcare professional, not is it meant to diagnose or treat a health problem, symptom or disease. Always speak with your physician or other healthcare professional before taking any medication or nutritional supplement, or using any treatment for a health problem. If you have or suspect that you have a medical problem, contact your health care provider promptly. Do not disregard professional medical advice or delay in seeking professional advice because of something you have read on this website. Information provided on this website DOES NOT create a doctor-patient relationship between you and any doctor affiliated with our website.
I am 41 and seem to have all the symptoms of low progesterone. I have had 5 miscarriages which now sound like they could have been because of low progesterone, which nobody was able to tell me after all the bloodwork under the sun! I gave up the idea of another child and I was sterilised about a year ago because i didnt want to take any chemical forms of birth control due to my mother’s breast cancer (which she subsequently died from) was the kind of cancer which feeds on estrogen. So i have this 7 day spotting before a period which the gynae said she could give me pills for but I’m terrified of taking chemicals because i dont want to get or encourage the same kind of cancer…what can i do? (Live in Sunny South Africa so Vit D levels are high!)
A molar pregnancy, which is an abnormal tissue growth in your uterus that develops as a result of a non-viable pregnancy, could also result in showing signs of elevated progesterone levels. The journal Obstetrics and Gynecology reported that a molar pregnancy causes an accumulation of progesterone because there is no fetus. The growth in the uterus triggers symptoms of pregnancy.14

If you take Clomid, your doctor will typically continue to have you monitor your progesterone levels after ovulation to make sure they rise appropriately. Progesterone supplements provide an easy fix for low progesterone levels. However, increasing progesterone levels will not prevent loss of an embryo with abnormal chromosomes after implantation. Clomid can also cause more than one follicle to develop; if you get pregnant with more than one embryo, your progesterone levels may rise higher than normal in early pregnancy.


There are two ways to use progesterone cream for PCOS. The first is the Suppression Cycle. To suppress the cycle one would use progesterone cream on cycle days 7-26. If you do not have a menstrual cycle you would choose a date on your calendar and mark it as day 7. Suppressing the cycle allows the body to rest by stopping the cycle of eggs not being released and estrogen/androgen dominance. Dr. John Lee suggests using 60-100mg of progesterone cream a day during the suppression cycle and to repeat this for 3-4 months for best results.

It is such a relief to finally know what I’m dealing with. I also was having fatigue, weight gain, palpitations and extreme brain fog. My PA that I go to  specializes in caring for midlife issues in women and she is a Godsend!  I would recommend finding a physician for those that are having these issues. It is so worth it. Thank you for your website and sharing the information. 
Progesterone is a key hormone for women’s health, having a great influence on your mood, sleep, period flow, bloating, weight and more. It is also important as the hormone that balances out our estrogen levels. Low progesterone can be associated with PMS, endometriosis, uterine fibroids, infertility, early miscarriage, PCOS, heavy periods and perimenopause. It is also associated with the development of breast cancer because of its role in counterbalancing estrogen.

IHR has treatments for a variety of conditions, including hormonal infertility, ovulatory dysfunctions, endometriosis, immunological infertility and many others. Perhaps less known is our work with individuals and couples who are considering assisted reproduction, but who are uncertain of their next step. We encourage anyone, before they make a decision, to consult with us. Currently, we are offering a FREE Hormonal Infertility E-Mail Consultation.


Progesterone changes the composition of the uterine lining, increasing the number of blood vessels so an embryo can implant. Progesterone levels in the first half of the menstrual cycle remain low. After ovulation, as the corpus luteum produces progesterone, levels should rise to 15 ng/mL or higher. Progesterone levels normally remain high for around 12 days after ovulation. When progesterone levels fall, the uterine lining breaks down and your menstrual period starts. If you have a luteal phase defect, the corpus luteum doesn't produce enough progesterone to maintain the lining and your period starts 10 days or less after ovulation.

If you use progesterone creams avoid applying over areas with an abundance of fatty tissue. This is because the cream can absorb and accumulate in the tissue rather than head straight into the blood stream.?Instead, apply your cream on areas with thin skin and veins. This way the hormones won’t build up and will instead all head into the bloodstream to be utilized quickly and efficiently.?The best areas are the neck/throat, arms, wrists, hands and on the top of your feet.
Hormone replacement therapy can help to relieve hormone fluctuation discomfort and help to prevent osteoporosis and delay some of the conditions associated with low estrogen. Low hormones have been linked to increased risk of heart disease, colon cancer, and Alzheimer's disease. Hormone replacement therapy is usually recommended mostly for short-term treatment. Prolonged treatment has been linked to an increased risk for breast and uterine cancer. Other risks associated with hormone replacement therapy may include the development of blood clots, heart attack, gallbladder disease, and stroke. Side effects of taking hormone therapy may include breast pain, nausea, fluid retention, and mood disorders. Some women experience spotting or bleeding when taking estrogen and progesterone therapy. Treatment for symptoms of low progesterone is usually not recommended for women who have a family or personal history of breast cancer, liver disease, or a family or personal history of diseases associated with the heart and blood vessels.
The level of estrogens, estrogen look-alikes and xenoestrogens rises in men's (and women's) bodies as the years go by. Progesterone opposes and balances excess estrogen (and xenoestrogens). It is progesterone that inhibits the harmful effects of too much estrogen (unopposed estrogen) more than anything else. So as estrogen levels rise in older men, there is no parallel rise in progesterone to balance this. A slight hormonal imbalance becomes a major imbalance - fast.
@Barbara, You’re right, taking a bio-identical hormone may negatively affect fertility when they are not needed. Progesterone can increase the chance of keeping a pregnancy in a woman who is chronically low. (to low progesterone and miscarriage is likely) And using some short term supplementation with progesterone can help a woman who is estrogen dominant.
Hey! I absolutely love your article. I have found it to be the most helpful and clear so far. I used to be the type of woman I could count on my periods like clock work. – Every 28 days on the dot. However, I got on birth control for a few years and when I got off everything change! I’ve had probably about 6 periods in the last year and a half. They are getting closer together but still not on track. My husband and I have been TTC and have had no such luck… I suppose I’ve had a bit of these symptoms since getting off birth control but they seem so much worse within the last month or two. Could it be due to progesterone? Or something else maybe? 
Unfortunately, for most this honeymoon does not last indefinitely. While some people continue to do well on such a program, many report this multiple hormone replacement approach gradually loses effectiveness over time. Those who are already in advanced stages of adrenal fatigue prior to beginning such program are particularly vulnerable. Over months or years, there is a slow but gradual loss of the positive clinical outcome as compared to the initial benefit. As time progresses, many return to their doctor for more help.

I saw my Dr. For an irregular and frequent cycle.  I am already vitamin D deficient and those symptoms seem to parallel low progestetone symptoms.  I am as uncomfortable as I was when I was pregnant and in my first trimester. Dull headache, tired, foggy etc.  So I will be treated for low progesterone with birth control…what are other treatments to address this hormone imbalance?

During the egg retrieval process, the cells that normally create progesterone after ovulation are removed along with the eggs. Progesterone supplements are then required to prepare the body for pregnancy and thicken the uterine lining to support successful embryo attachment in the womb. Progesterone may also be required during the pregnancy to safeguard against pregnancy loss. Continuation of progesterone supplementation is advisable, on an individual basis, even up to 12 weeks of pregnancy in a cycle where embryo transfer is done.
Miguel Cavazos is a photographer and fitness trainer in Los Angeles who began writing in 2006. He has contributed health, fitness and nutrition articles to various online publications, previously editing stand-up comedy and writing script coverage as a celebrity assistant. Cavazos holds a Bachelor of Arts in philosophy and political science from Texas Christian University.
[Figure 40-7 on p. 514 from the NaPro textbook. A woman with premenstrual spotting, a history of four consecutive spontaneous abortions and a preovulatory and postovulatory hormone profile. The periovulatory estradiol levels are decreased but what is most remarkable is the significant decrease in postovulatory progesterone (From: Pope Paul VI Institute research, 2004).]
Progesterone is one of the female hormones associated with monthly menstrual cycles. In particular, progesterone helps maintain the lining of the uterus during the weeks that follow ovulation, so that if an egg is fertilized, it has somewhere to implant. High progesterone levels, however, can lead to a variety of uncomfortable symptoms, many of them PMS-like in nature.
High progesterone levels may be determined for several reasons. These tests may be ordered to assess infertility. The test can determine if the woman is ovulating normally. If the ovulation is not normal, the test can tell what type of drug therapy may be helpful. If a woman has symptoms such as abdominal pain or spotting, the doctor may suspect an ectopic pregnancy or a possible miscarriage. For some women, injections of the hormone may help maintain a threatened pregnancy, so the test will show how much hormone she may need. When a doctor monitors a high-risk pregnancy, he may order one of these tests. And if a woman is experience progesterone side effects such as abnormal uterine bleeding, the test will confirm the diagnosis.

Also please stay away from all scented lotions and laundry detergents, air fresheners, cleaners etc….The chemicals can can caus estrogen dominance flare ups! I love unscented micellar water wipes to moisturize with. Or an unscented oil in the shower works well for especially dry areas but don’t slater from head to toe…your skin needs to breath. These fragrenced products are proven to cause endocrine disruption and once I cut them all out as much as possible I noticed a HUGE difference.
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