During menopause, estrogen is no longer produced by the ovaries and is made in smaller amounts by the adrenal glands and in fat tissue. Estrogen is still produced in the body, but in lower amounts than younger cycling women. The most significant hormone change of menopause is the lack of progesterone, so a time of estrogen dominance and low progesterone.
Depending of the route of administration, there may be no side effects, especially with vaginal preparations, which have a direct uterine effect, rather than a systemic one. Vaginal discharge or irritation are possible with these forms.  If injectable or oral preparations are used, side effects may include pain, swelling and bruising at the injection site, headaches, breast tenderness, drowsiness, dizziness, fluid retention, bloating, hot flashes, constipation, and everything that mimics pregnancy symptoms! These symptoms may persist into a pregnancy as well, or stop when the drug is withdrawn.

I have every single symptom above and have been trying to deal with these symptoms for a year and a half. My doctor refers me to my gynecologist who says it is depression/anxiety. I have tried multiple different antidepressants and anti-anxiety medications because the second half of my cycle I turn into a crazy monster (PMS/PMDD). I had my tubes clipper 7 years ago after having my son because my husband at the time did not want more kids. We are no longer married and I am now married to a wonderful man and we would like to have another child. He has been amazing trying to help me deal with all of this and find solutions. I am going to hopefully being having my clips removed in the next few months but before doing that my doctor wanted me to do several tests. The nurse called me today and said my progesterone level is low and she wants me to go on Clomid for cycle. I want to know if going on Clomid will help my levels OR if I should ask my dr to put me on Progesterone. I really need some advice because this has been super difficult trying to deal with. 
If you have breast pain, you have unopposed an estrogen dominance issue even if tests show “normal” level of progesterone. I had the same issues with estrogen dominance breast pain. I read about and tried topical iodine therapy along with prometrrium (bio identical progesterone) prescribed by my gyno….this worked great for all my pms and then peri menopause symptoms. Whenever I have a flare up of breast pain, I generously coat the iodine evenly over breasts and it works within hours! I was amazed it actually worked! Studies show your body will only absorb the amount of iodine it needs so no risk of overdosing on it. I buy the individually wrapped iodine pads and keep some with me at all times. Also I have tried over the counter progesterone creams and only had intolerable side effects. Ask your doctor if you can give Prometrium a try. In fact don’t ask TELL your doc you want to try it and if they won’t find a new gyno who is more up to date!
Finally, for those individuals that have migraine headaches or headaches, particularly for those headaches or migraine headaches that occur premenstrually, it’s not because you have low levels of Imitrex or Cafergot in your body or some other $50 pharmaceutical drug. Those drugs don’t solve the problem of the migraine. Migraine headaches can be caused by low levels of progesterone, progesterone deficiency. So, if you have migraines that are cyclical and occur routinely right around your menstrual cycle or just before, then those are more than likely going to be hormonal. If you have migraine headaches that occur anytime during the month, that can be due to low levels of magnesium.
hey! i used to have very cold hands and feet and body aches and heavy periods. i didnt really have a lot of strength and i was usually moody. then i got married and moved in with my husband. i started feeling a lot better, my aches were gone but now my period has become much shorter, the blood is pinkish and i hardly see any tissue on my pad. its also gotten more painful. i looked up online and i think it might be because of low progesterone. i was so happy because i thought i ws getting healthier but im scared now as i want to concieve. i have always been a little underweight with high blood cholesterol but that has always been that way. please help
During childbearing years, progestin reduces the risk of endometrial cancer. Someone who has polycystic ovary syndrome or is over weight or under weight may need to take birth control pills to counteract the progression of the disease. On average, women enter menopause at age 52, at which time they may experience high progesterone levels. The progesterin may fluctuate wildly, increasing and decreasing. Periods become irregular and hot flashes may occur. That's a time when health professionals may recommend some type of therapy to counteract the progesterone side effects, whether it is low or elevated. The normal therapy is administering low doses of birth control pills. This is a time when the body produces only a fraction of the estrogen it once did. A balance between estrogen and progestin is necessary for good health. For women who have problems with these therapies, the medication may be administered only four times a year.
Sufficient vitamin D. Please get your vitamin D level tested. Your result should be at least 30-49 ng/ml or 75-124 nmol/L but preferably higher. A level of vitamin D lower than this will slow or prevent your body making its own progesterone, and low levels of progesterone also make its actions less effective. Getting a good level of vitamin D is often one of the keys to treating symptoms of low progesterone. Most people are vitamin D deficient, particularly during the dark gloomy days of winter. If your vitamin D level is low when you use progesterone you are not really giving it a chance, and you may (incorrectly) think that progesterone is ineffective.

I was diagnosed with endometriosis almost 4 years ago and had a second laparoscopy in January 2012 by a specialist to have it removed. After waiting six months past surgery my husband and I started trying to conceive. I had a very early miscarriage 6 months ago. I have had issues with spotting for a very long time and after starting to chart my temperature about 7 months ago I now have a better idea of when I have the spotting. It usually occurs for a few days after my period and then starts again 3-6 days past ovulation and continues until I get my period. My doctor thought it may be due to low progesterone and put me on progesterone pills during the luteal phase over two months ago. This has not helped with the spotting at all. I have also been doing acupuncture for several months which has helped even out my temperatures throughout the month but has not helped with the spotting either. I have consistently been having a temperature drop on day 10 or 11 that is not associated with ovulation (it occurs at a few days later with another temperature drop and then rise). I have several days of LH surge, usually 3 days but last month 5 days. Anyway I’m not sure what all of this means and what else I can do. Could it be that I have low estrogen? Could taking Estrosense or Vitex or both help? Should I continue the progesterone pills? Any helpful insight would be greatly appreciated! Oh and I try to eat very healthy, organic and only the very occasional grass fed livestock.

So, the proliferative hormone is estrogen. The balancing hormone, the restraining hormone is progesterone. Those two hormones, when they’re in balance women feel wonderful. Okay? Progesterone means promoting gestation, promoting pregnancy. So, it’s the hormone that promotes the pregnancy by maturing the inner lining of the womb. Now as a woman marches through her menstrual life, by the time they hit their mid 30s into their 40s, the ovaries begin to produce lower and lower levels of progesterone. While estrogen levels may fall too, they don’t fall as dramatically as progesterone. So, they come into a problem known as estrogen dominance, or the other side of the coin is progesterone deficiency. They become deficient in progesterone.

Adi, I am right there with you! I am the same height as you and was diagnosed with HA at 114 pounds. I reduced exercise to walking and yoga only and gained up to a BMI of 22.3 before my cycle returned, though irregular. You can do this! You know what has to be done and are working towards changing your lifestyle so you can be healthy on the inside, good for you!
Hi! I have low progesterone, as well as very low estradiol and testosterone levels. I just turned 43 and for two years, my hormonal decline has taken my life away. I have no energy whatsoever: Crashing fatigue. I do have hashimotos, but it’s pretty much under control (I’m well versed there). I have known that my progesterone has been dropping for the last 9 years but have had trouble tolerating progesterone. Within two weeks my face turns into a cystic mess and I feel rage. Now that my estradiol is low, I have to find a way to take progesterone in order to supplement with an estradiol/estriol combo. What on earth would cause me to be intolerable to progesterone? I have been trying to take an OTC progesterone oil sublingually. So far, I still break out some, but my feeling is that I’m just not on enough and I fear increasing the dose. I mean, who wants wrinkles and zits at 43 lol? Is it just possible that I’m not taking a high enough dose to stop this madness that I have battled for 9 years? Something’s got to give because my business has come to a stand still and my children no longer have a mother who has the energy to do anything. And sleep? What’s that? Between the insomnia and hot flashes I’m about to lose my mind. Thank you kindly for any advice you can share with me. P.s. I have seen several so-called bioidentical docs and they just seem stumped by me :(.
These fight or flight hormones have enormous impacts and lead to chronic symptoms of hormone imbalance. This happens because your body thinks you’re in an unsafe environment and drops progesterone levels to ensure the lining of your uterus is not-conception friendly. This makes sense, given that your brain signals are saying your life is under threat. As a result, you may develop Luteal Phase Insufficiency.
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